A Specific Negatively Charged Sequence Confers Intramolecular Regulation on Munc13-1 Function in Synaptic Exocytosis

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Biophysics,
Munc13-1   synaptic exocytosis   negatively charged sequence   autoinhibition   calcium regulation   protein structure   neurotransmitter release  

Unlocking a New Mechanism for the Regulation of Neurotransmitter Release: A Review of Munc13-1’s Novel Autoinhibitory Structure and Its Calcium-Modulated Role I. Academic Background and Research Motivation Signal transmission between neurons relies on chemical synapses, with precise neurotransmitter release from presynaptic terminals via synaptic e...