E3 Ligase TRIM63 Promotes Chondrogenic Differentiation of Mesenchymal Stem Cells by Catalyzing K27-Linked Cysteine Ubiquitination of MYH11

Medicine, Orthopedics, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
TRIM63   mesenchymal stem cells   chondrogenic differentiation   ubiquitination   MYH11   cartilage repair   osteoarthritis  

Research Progress on the Role of E3 Ubiquitin Ligase TRIM63 in Promoting Chondrogenic Differentiation of Mesenchymal Stem Cells — An Interpretation of the Paper “E3 ligase TRIM63 promotes the chondrogenic differentiation of mesenchymal stem cells by catalyzing K27-linked cysteine ubiquitination of MYH11” 1. Academic Background and Research Motivati...

DDX5 Inhibits Hyaline Cartilage Fibrosis and Degradation in Osteoarthritis via Alternative Splicing and G-Quadruplex Unwinding

Medicine, Orthopedics, Basic Medical Sciences, Geriatrics,
osteoarthritis   hyaline cartilage   fibrosis   DDX5   alternative splicing   G-quadruplex  

The Novel Mechanism of DDX5 in Inhibiting Hyaline Cartilage Fibrosis and Degradation in Osteoarthritis Background Osteoarthritis (OA) is a chronic degenerative disease characterized mainly by the degradation, degeneration, and osteophyte formation of joint cartilage. Hyaline cartilage fibrosis is often considered the end-stage lesion of OA, leading...

Distribution of Coronal Plane Alignment of the Knee Classification in Chinese Osteoarthritic and Healthy Population: A Retrospective Cross-sectional Observational Study

Medicine, Rheumatology and Immunology, Orthopedics, Medical Imaging,
coronal plane alignment   knee   kinematic alignment   osteoarthritis   total knee arthroplasty  

A Retrospective Cross-Sectional Observational Study on the Distribution of Coronal Plane Alignment Classifications in Chinese Osteoarthritic and Healthy Populations Research Background Neutral mechanical alignment (MA) of the knee is considered the cornerstone of successful and durable total knee arthroplasty (TKA). However, the existence of “const...