E3 Ligase TRIM63 Promotes Chondrogenic Differentiation of Mesenchymal Stem Cells by Catalyzing K27-Linked Cysteine Ubiquitination of MYH11

Medicine, Orthopedics, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
TRIM63   mesenchymal stem cells   chondrogenic differentiation   ubiquitination   MYH11   cartilage repair   osteoarthritis  

Research Progress on the Role of E3 Ubiquitin Ligase TRIM63 in Promoting Chondrogenic Differentiation of Mesenchymal Stem Cells — An Interpretation of the Paper “E3 ligase TRIM63 promotes the chondrogenic differentiation of mesenchymal stem cells by catalyzing K27-linked cysteine ubiquitination of MYH11” 1. Academic Background and Research Motivati...

Alcaligenes faecalis Induces Intestinal T Helper 17 Cells by Promoting E3 Ubiquitin Ligase TRIM21-Mediated FBXW7 Degradation

Medicine, Rheumatology and Immunology, Life Sciences, Cell Biology, Biochemistry, Immunology, Microbiology,
Alcaligenes faecalis   Th17 cells   TRIM21   FBXW7   ubiquitination   intestinal immunity   cell differentiation  

1. Research Background Intestinal Th17 cells play a central role in maintaining mucosal immune homeostasis and defending against pathogen infections. Previous studies identified segmented filamentous bacteria (SFB) as key microbes inducing intestinal Th17 cells, but controversies exist regarding SFB colonization in adult intestines: 1. Clinical Par...

Molecular Mechanisms of Tumor Necrosis Factor Receptor-Associated Factor 7 in Cardiac Hypertrophy

Medicine, Cardiovascular System,
cardiac hypertrophy   TRAF7   ASK1   ubiquitination   molecular mechanisms  

Academic Background Cardiac hypertrophy is a common pathophysiological process in the development of various cardiovascular diseases, such as hypertension, myocardial infarction, and congenital heart disease. Although cardiac hypertrophy is an adaptive response of the heart to adverse stimuli, long-term pathological cardiac hypertrophy can lead to ...

TRIM21-Mediated Ubiquitination and Phosphorylation of ERK1/2 Promotes Cell Proliferation and Drug Resistance in Pituitary Adenomas

Medicine, Endocrinology, Neurology, Neurosurgery, Oncology,
TRIM21   ERK1/2   pituitary adenomas   cell proliferation   drug resistance   ubiquitination   phosphorylation  

Academic Background Pituitary adenomas (PAs) are common intracranial tumors with complex pathogenesis, often accompanied by abnormal hormone secretion. Although various treatments, such as dopamine agonists (DAs), are currently available, some patients exhibit drug resistance, leading to suboptimal therapeutic outcomes. Therefore, identifying new t...

USP35 Promotes Breast Cancer Progression by Regulating PFK-1 Ubiquitination to Mediate Glycolysis

Medicine, Oncology,
breast cancer   ubiquitination   glycolysis   PFK-1   USP35  

USP35 Promotes Breast Cancer Progression by Regulating PFK-1 Ubiquitination to Mediate Glycolysis Academic Background Breast cancer is the most common malignant tumor affecting women worldwide and remains a leading cause of cancer-related mortality among women. Despite the development of various treatment strategies for different molecular subtypes...