Research Background Natural products have long played a crucial role in drug discovery, providing many biologically active compounds and fundamental principles for drug development. However, the synthetic exploration of natural products is not limited to the pharmaceutical field; their applications in materials science are gradually gaining attenti...

Academic Background In the fields of materials science and chemistry, understanding the properties of materials at the atomic level is crucial. However, traditional methods for calculating interatomic potentials, such as Density Functional Theory (DFT), while highly accurate, are computationally expensive and difficult to apply to large-scale syste...

In the field of medicinal chemistry, molecular diversification is a crucial step in the discovery of new drugs. However, existing catalytic methods often face challenges when dealing with complex drug molecules, as these molecules are typically more complex than simple substrates. In particular, the formation of carbon-heteroatom (C–X) bonds is an ...

Academic Background Hydrogenolysis, a fundamental chemical reaction that breaks chemical bonds through the addition of molecular hydrogen, is widely used in the upgrading of biomass, petroleum, and other feedstocks into high-value chemicals and fuels. Additionally, hydrogenolysis plays a crucial role in the pharmaceutical and fine chemical industri...

Novel Benzene-Containing Polyketides and Modified Diketopiperazine from Actinomycete of the Genus Cryptosporangium Academic Background Microbial natural products hold significant value in drug development, particularly actinomycetes, which provide a rich source of various therapeutic compounds, such as aminoglycosides, macrolides, and tetracyclines...