IL-10 Sensing by Lung Interstitial Macrophages Prevents Bacterial Dysbiosis-Driven Pulmonary Inflammation and Maintains Immune Homeostasis

1. Research Background The pathogenesis of chronic lung inflammation and pulmonary fibrosis remains unclear, particularly regarding the interaction between pulmonary commensal microbiota and the immune system. While interleukin-10 (IL-10), a key anti-inflammatory cytokine, has been extensively studied in gut homeostasis, its role in pulmonary immun...

TREM2 Deficiency Reprograms Intestinal Macrophages and Microbiota to Enhance Anti–PD-1 Tumor Immunotherapy

TREM2 Deficiency Reprograms Intestinal Macrophages and Microbiota to Enhance Anti–PD-1 Tumor Immunotherapy

TREM2 Deficiency Reprograms Gut Macrophages and Microbiota to Enhance Anti-PD-1 Tumor Immunotherapy Background Immune checkpoint inhibitors (CPIs), such as drugs that block programmed cell death protein-1 (PD-1), programmed death-ligand 1 (PD-L1), and cytotoxic T-lymphocyte-associated protein-4 (CTLA-4), have been successfully used to activate anti...