TDP-43 Nuclear Loss in FTD/ALS Causes Widespread Alternative Polyadenylation Changes

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
TDP-43   frontotemporal dementia   amyotrophic lateral sclerosis   RNA processing   alternative polyadenylation   neurodegeneration   biomarker  

Introduction and Academic Background Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are two severe neurodegenerative diseases whose pathogenic mechanisms remain incompletely understood. In recent years, the RNA-binding protein TDP-43 (TAR DNA-binding protein 43) has been recognized as playing a central pathological role in bo...

TDP-43 Loss Induces Cryptic Polyadenylation in ALS/FTD

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
TDP-43   cryptic polyadenylation   ALS   FTD   RNA processing   neurodegeneration  

TDP-43 Loss Induces Cryptic Polyadenylation in ALS/FTD Background Introduction Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two severe neurodegenerative diseases affecting hundreds of thousands of people worldwide. Extensive research has shown that the RNA-binding protein TDP-43 (TAR DNA-binding protein 43) displays abn...