TDP-43 Nuclear Loss in FTD/ALS Causes Widespread Alternative Polyadenylation Changes

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
TDP-43   frontotemporal dementia   amyotrophic lateral sclerosis   RNA processing   alternative polyadenylation   neurodegeneration   biomarker  

Introduction and Academic Background Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are two severe neurodegenerative diseases whose pathogenic mechanisms remain incompletely understood. In recent years, the RNA-binding protein TDP-43 (TAR DNA-binding protein 43) has been recognized as playing a central pathological role in bo...

Aberrant splicing exonizes C9orf72 repeat expansion in ALS/FTD

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
aberrant splicing   C9orf72   repeat expansion   ALS   frontotemporal dementia   DPR proteins   therapeutic targets  

New Pathway for ALS/FTD-Related C9orf72 Pathogenesis Revealed by Latest Nature Neuroscience Study Academic Background and Research Motivation Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are among the most challenging neurodegenerative diseases in clinical medicine, with complex pathogenesis that remains insufficiently expl...

Proteomic Analysis Reveals Distinct Cerebrospinal Fluid Signatures Across Genetic Frontotemporal Dementia Subtypes

Medicine, Medical Laboratory Science, Neurology, Life Sciences, Biochemistry, Genetics,
proteomics   frontotemporal dementia   cerebrospinal fluid   genetic mutations   neurodegenerative diseases  

Academic Background Frontotemporal Dementia (FTD) is a group of progressive neurodegenerative diseases characterized primarily by behavioral changes, language impairment, or motor dysfunction. Although the incidence of FTD is lower than that of Alzheimer’s Disease (AD), it remains one of the leading causes of early-onset dementia. The molecular bas...