TDP-43 Seeding Induces Cytoplasmic Aggregation Heterogeneity and Nuclear Loss of Function of TDP-43
Academic Background TDP-43 (TAR DNA-binding protein 43) is an RNA-binding protein primarily located in the nucleus, involved in multiple processes of RNA metabolism, including transcription, splicing, RNA transport, and translation. However, in various neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementi...