TDP-43 Nuclear Loss in FTD/ALS Causes Widespread Alternative Polyadenylation Changes

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
TDP-43   frontotemporal dementia   amyotrophic lateral sclerosis   RNA processing   alternative polyadenylation   neurodegeneration   biomarker  

Introduction and Academic Background Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are two severe neurodegenerative diseases whose pathogenic mechanisms remain incompletely understood. In recent years, the RNA-binding protein TDP-43 (TAR DNA-binding protein 43) has been recognized as playing a central pathological role in bo...

TDP-43 Loss Induces Cryptic Polyadenylation in ALS/FTD

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
TDP-43   cryptic polyadenylation   ALS   FTD   RNA processing   neurodegeneration  

TDP-43 Loss Induces Cryptic Polyadenylation in ALS/FTD Background Introduction Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two severe neurodegenerative diseases affecting hundreds of thousands of people worldwide. Extensive research has shown that the RNA-binding protein TDP-43 (TAR DNA-binding protein 43) displays abn...

TDP-43 Seeding Induces Cytoplasmic Aggregation Heterogeneity and Nuclear Loss of Function of TDP-43

Medicine, Basic Medical Sciences, Neurology, Life Sciences,
TDP-43   cytoplasmic aggregation   nuclear loss of function   neurodegenerative disorders   amyloid-like fibrils  

Academic Background TDP-43 (TAR DNA-binding protein 43) is an RNA-binding protein primarily located in the nucleus, involved in multiple processes of RNA metabolism, including transcription, splicing, RNA transport, and translation. However, in various neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementi...

Aberrant Splicing in Huntington’s Disease Accompanies Disrupted TDP-43 Activity and Altered m6A RNA Modification

Medicine, Neurology, Life Sciences, Cell Biology, Genetics,
Huntington’s Disease   TDP-43   m6A RNA modification   aberrant splicing   neurodegenerative disorder  

Aberrant Splicing in Huntington’s Disease Accompanies Disrupted TDP-43 Activity and Altered m6A RNA Modification Academic Background Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms. The disease is caused by a CAG repeat expansion in the HTT gene, leading to ab...

Comprehensive Assessment of TDP-43 Neuropathology Data in the National Alzheimer’s Coordinating Center Database

Medicine, Medical Laboratory Science, Geriatrics, Neurology,
TDP-43   Limbic Predominant Age-Related TDP-43 Encephalopathy Neuropathologic Change   Frontotemporal Lobar Degeneration   Amyotrophic Lateral Sclerosis   Hippocampal Sclerosis of Aging   Dementia   Alzheimer’s Disease  

Research Report Titled “Comprehensive Evaluation of TDP-43 Neuropathology Data in the National Alzheimer’s Coordinating Center Database” Research Background TDP-43 proteinopathy is a significant neuropathological feature in frontotemporal lobar degeneration (FTLD-TDP), amyotrophic lateral sclerosis (ALS-TDP), and age-related limbic TDP-43 encephalo...

Annexin A11 Aggregation in FTLD-TDP Type C and Related Neurodegenerative Disease Proteinopathies

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
neurodegenerative disease   TDP-43   FTLD-TDP   ALS   Annexin A11  

Study on Annexin A11 Aggregation and TDP-43 Proteinopathies in Neurodegenerative Diseases In this research report published in Acta Neuropathologica, researchers led by John L. Robinson from the University of Pennsylvania investigate the aggregation phenomena of Annexin A11 in neurodegenerative diseases, particularly in FTLD-TDP Type C, which is as...