Adult Human Heart Extracellular Matrix Improves Human iPSC-CM Function via Mitochondrial and Metabolic Maturation

Medicine, Basic Medical Sciences, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
extracellular matrix   iPSC-derived cardiomyocyte   functional maturation   mitochondrial maturation   metabolic maturation   cell therapy  

1. Academic Background Cardiovascular diseases, especially myocardial infarction (MI), are among the leading causes of death and disability worldwide. After a myocardial infarction, up to one billion cardiomyocytes (CM) can be lost in just a few hours. However, adult myocardial tissue itself has extremely low regenerative capacity, which means the ...

Gene Therapy: Genetic Engineering of Transfusable Platelets with mRNA-Lipid Nanoparticles is Compatible with Blood Banking Practices

Medicine, Hematology, Life Sciences,
gene therapy   platelets   mRNA-lipid nanoparticles   blood banking   transfusion   cell therapy   clinical compatibility  

Report on the Compatibility of mRNA-Lipid Nanoparticle-Based Gene-Engineered Platelets with Blood Banking Practices Academic Background Platelets play an essential role in hemostasis, inflammation, sepsis, and cancer. However, clinical applications of platelet transfusions are primarily limited to managing thrombocytopenia and bleeding. To broaden ...

Mesenchymal Stromal Cells with Chimeric Antigen Receptors for Enhanced Immunosuppression

Medicine, Rheumatology and Immunology, Life Sciences, Cell Biology, Immunology, Humanities and Others,
mesenchymal stromal cells   chimeric antigen receptors   immunosuppression   graft-versus-host disease   cell therapy  

Mesenchymal Stromal Cells with Chimeric Antigen Receptors for Enhanced Immunosuppression Background Mesenchymal Stromal Cells (MSCs) are pluripotent cells found in almost all tissues and possess significant immunosuppressive and regenerative properties. These features make MSCs widely studied for the treatment of immune diseases and tissue regenera...