Platelet-Activating Factor: A Potential Therapeutic Target to Improve Cancer Immunotherapy

Medicine, Oncology, Life Sciences, Immunology,
tumor microenvironment   immunosuppression   platelet-activating factor   neutrophils   cancer immunotherapy  

The Potential Role of Platelet-Activating Factor in Cancer Immunotherapy Background Cancer immunotherapy has been a significant breakthrough in cancer treatment in recent years, but its efficacy is still limited by the immunosuppressive mechanisms within the tumor microenvironment (TME). The TME supports the differentiation and proliferation of mye...

The Antitumor Activity of TGFβ-Specific T Cells is Dependent on IL-6 Signaling

Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Cell Biology, Immunology,
TGFβ   IL-6   immunosuppression   tumor microenvironment   vaccines  

Review of the Study on the Relationship Between IL-6 Signaling and the Anti-Tumor Activity of TGFβ-Specific T Cells Background and Significance of the Study Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a critical role in inflammation and hematopoiesis. However, its role in the immune system is context-dependent. While it has pro-inflam...

Kynurenine-AHR Reduces T-Cell Infiltration and Induces a Delayed T-Cell Immune Response by Suppressing the STAT1-CXCL9/CXCL10 Axis in Tuberculosis

Medicine, Infectious Diseases, Life Sciences, Immunology,
tuberculosis   tryptophan metabolism   IDO1   immunosuppression   chemokines   T-cell infiltration   STAT1 signaling pathway  

Research Background and Motivation Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a global health issue infecting and killing millions annually. Despite advances in TB diagnosis and treatment, the immune evasion strategies employed by Mtb remain a critical reason for its prolonged survival in the host, leading to chronic infectio...

Ubiquitin Regulatory X (UBX) Domain-Containing Protein 6 is Essential for Autophagy Induction and Inflammation Control in Macrophages

Medicine, Rheumatology and Immunology, Life Sciences, Cell Biology, Biochemistry, Immunology,
UBXN6   sepsis   inflammation   autophagy   immunosuppression  

Critical Role of UBXN6 in Autophagy Induction and Inflammation Control in Macrophages Background The innate immune system serves as the first line of defense against pathogen invasion and inflammatory responses. Monocytes and macrophages, as key cell types in the innate immune system, play critical roles during infection and inflammation. However, ...

JAK2/mTOR Inhibition Fails to Prevent Acute GVHD Despite Reduced Th1/Th17 Cells: Final Phase 2 Trial Results

Medicine, Hematology, Life Sciences, Immunology,
JAK2/mTOR inhibition   acute GVHD   Th1/Th17 cells   allogeneic hematopoietic cell transplantation   clinical trial   immunosuppression   cell differentiation  

Inhibition of JAK2/mTOR Fails to Effectively Prevent Acute Graft-versus-Host Disease (GVHD): Limitations of Targeting Th1/Th17 Cells In recent years, the role of systemic immunosuppressive therapies in preventing acute graft-versus-host disease (aGVHD) following allogeneic hematopoietic cell transplantation (alloHCT) has come under scrutiny. Th1 (T...