DockEM: An Enhanced Method for Atomic-Scale Protein–Ligand Docking Refinement Leveraging Low-to-Medium Resolution Cryo-EM Density Maps

Chemistry, Medicinal Chemistry, Computational Chemistry, Life Sciences, Biochemistry, Biophysics,
protein-ligand docking   cryo-EM   molecular docking   drug screening   structural biology  

Academic Background and Research Motivation In recent years, protein–ligand docking has rapidly developed as a core technology for virtual drug screening and structure-based drug discovery. Despite improvements in drug discovery efficiency through large-scale high-throughput screening technologies, new drug development still faces high costs, long ...

3D Bioprinting of Tumor Models and Potential Applications

Medicine, Oncology, Life Sciences, Bioengineering,
3D bioprinting   tumor models   tumor microenvironment   bioinks   drug screening   precision medicine   tumor immunotherapy  

3D Bioprinting of Tumor Models and Their Potential Applications: A Review Academic Background Cancer is one of the leading causes of human mortality worldwide. Its uncontrolled abnormal proliferation, rapid growth, metastasis, and high heterogeneity result in extremely low clinical translation rates for traditional two-dimensional (2D) cell culture...