Problem Solving Protocol: Accurate Residue-Level Phase Separation Prediction Using Protein Conformational and Language Model Embeddings

Life Sciences, Biochemistry, Genetics, Biophysics,
phase separation   language model   residue-level prediction   conformational embeddings   intrinsically disordered regions  

1. Academic Background and Research Significance In recent years, protein liquid–liquid phase separation (PS) has emerged as a key mechanism regulating biomolecules inside cells, attracting widespread attention in the life sciences. Phase separation not only drives the formation of biomolecular condensates (membraneless organelles), but also extens...

Contrastive Learning of T Cell Receptor Representations

Medicine, Life Sciences, Cell Biology, Biochemistry, Immunology,
T cell receptor   contrastive learning   sequence alignment   specificity prediction   language model  

New Breakthrough in T Cell Receptor (TCR) Specificity Prediction: The Introduction of the SCEPTR Model Academic Background T cell receptors (TCRs) play a crucial role in the immune system by determining the specificity of immune responses through their binding to peptide-MHC complexes (pMHCs). Understanding the interaction between TCRs and specific...

Protein Structure Prediction: Challenges, Advances, and the Shift of Research Paradigms

Information Science, Computer Science, Artificial Intelligence, Life Sciences, Cell Biology, Biochemistry, Biophysics,
protein folding   protein structure prediction   deep learning   transformer   language model  

Protein Structure Prediction: Challenges, Progress, and Shifts in Research Paradigms Protein structure prediction is an important interdisciplinary research topic that has attracted researchers from various fields including biochemistry, medicine, physics, mathematics, and computer science. Researchers have adopted multiple research paradigms to so...

A 5' UTR Language Model for Decoding Untranslated Regions of mRNA and Function Predictions

A 5' UTR Language Model for Decoding Untranslated Regions of mRNA and Function Predictions

Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
language model   5' UTR   mRNA translation   protein expression   function prediction  

The 5’ untranslated region (5’UTR) is a regulatory region at the start of messenger RNA (mRNA) molecules, playing a crucial role in regulating the translation process and affecting protein expression levels. Language models have demonstrated effectiveness in decoding protein and genomic sequence functions. In this study, the authors introduce a lan...