Fibroblast Activation Protein-α Interacts with CXCL12 to Inactivate Canonical Wnt Signaling and Regulate Osteoblast Differentiation

Medicine, Orthopedics, Basic Medical Sciences, Geriatrics, Endocrinology, Life Sciences, Cell Biology, Biochemistry,
fibroblast activation protein-α   CXCL12   Wnt/β-catenin pathway   osteoblast differentiation   adipocyte differentiation   osteoporosis   mesenchymal progenitor cells  

Academic Research Background With the global population aging rapidly, osteoporosis has gradually become a major disease threatening public health. Characterized by reduced bone mass and deterioration of bone microarchitecture, osteoporosis significantly increases the risk of fractures, severely impacts the quality of life of the elderly, and bring...

PDGFR Marks Distinct Mesenchymal and Pericyte Populations Within the Periosteum With Overlapping Cellular Features

Medicine, Orthopedics, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
periosteum   PDGFRβ   mesenchymal progenitor cells   pericytes   bone regeneration   single-cell RNA sequencing  

New Developments in Bone Regeneration: The Discovery of PDGFRβ-marked Distinct Mesenchymal and Pericyte Subpopulations in the Periosteum — Interpretation of “pdgfr marks distinct mesenchymal and pericyte populations within the periosteum with overlapping cellular features” 1. Research Background and Scientific Question The periosteum, a thin vascul...