Fibroblast Activation Protein-α Interacts with CXCL12 to Inactivate Canonical Wnt Signaling and Regulate Osteoblast Differentiation

Medicine, Orthopedics, Basic Medical Sciences, Geriatrics, Endocrinology, Life Sciences, Cell Biology, Biochemistry,
fibroblast activation protein-α   CXCL12   Wnt/β-catenin pathway   osteoblast differentiation   adipocyte differentiation   osteoporosis   mesenchymal progenitor cells  

Academic Research Background With the global population aging rapidly, osteoporosis has gradually become a major disease threatening public health. Characterized by reduced bone mass and deterioration of bone microarchitecture, osteoporosis significantly increases the risk of fractures, severely impacts the quality of life of the elderly, and bring...

Critical Role of the Potential O-Linked Glycosylation Sites of CXCR4 in Cell Migration and Bone Marrow Homing of Hematopoietic Stem Progenitor Cells

Medicine, Basic Medical Sciences, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology,
CXCR4   O-linked glycosylation   hematopoietic stem progenitor cells   cell migration   bone marrow homing   glycosylation   CXCL12  

1. Academic Background and Research Origin Hematopoietic stem/progenitor cells (HSPCs) are the foundation for maintaining the steady state of the adult blood system. Every day, the human body needs to generate billions of new blood cells—a process that relies on the capacity of HSPCs for self-renewal and directed differentiation within the bone mar...