Brain Tumors Induce Widespread Disruption of Calvarial Bone and Alteration of Skull Marrow Immune Landscape

Medicine, Basic Medical Sciences, Neurology, Neurosurgery, Hematology, Medical Imaging, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
brain tumor   calvarial bone   skull marrow   immune microenvironment   single-cell RNA sequencing   osteoclast   immune cell alteration  

A New Role for Skull Marrow Immune Microenvironment in Brain Tumors: Interpretation Based on Multicenter Studies in Mice and Humans 1. Academic Background and Research Significance Brain tumors, especially glioblastoma (GBM), are among the most aggressive malignant tumors in the central nervous system. Traditionally, they were considered localized ...

PDGFR Marks Distinct Mesenchymal and Pericyte Populations Within the Periosteum With Overlapping Cellular Features

Medicine, Orthopedics, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
periosteum   PDGFRβ   mesenchymal progenitor cells   pericytes   bone regeneration   single-cell RNA sequencing  

New Developments in Bone Regeneration: The Discovery of PDGFRβ-marked Distinct Mesenchymal and Pericyte Subpopulations in the Periosteum — Interpretation of “pdgfr marks distinct mesenchymal and pericyte populations within the periosteum with overlapping cellular features” 1. Research Background and Scientific Question The periosteum, a thin vascul...

Unveiling a Novel Cancer Hallmark by Evaluation of Neural Infiltration in Cancer

Medicine, Oncology, Life Sciences, Cell Biology, Immunology, Genetics,
neural infiltration   cancer hallmark   tumor microenvironment   single-cell RNA sequencing   immunotherapy  

Cancer, as a major global public health challenge, is characterized by complex mechanisms underlying its onset and progression. For a long time, processes within the tumor microenvironment (TME)—such as immunity, inflammation, and angiogenesis—have been extensively studied and considered key determinants of tumor biological behavior. In recent year...

Single-Cell Unified Polarization Assessment of Immune Cells

Information Science, Computer Science, Life Sciences, Cell Biology, Immunology,
single-cell RNA sequencing   immune cell polarization   cytokine-driven   computational method   tumor infiltration   transcriptome   cell embeddings  

Immune cells undergo cytokine-driven polarization in response to various stimuli, which alters their transcriptional profiles and functional states. This dynamic process plays a central role in immune responses in both health and disease. However, there has been a lack of systematic methods to assess cytokine-driven polarization in single-cell RNA ...

Multimodal Learning for Mapping Genotype–Phenotype Dynamics

Information Science, Computer Science, Artificial Intelligence, Medicine, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
multimodal learning   genotype-phenotype relationship   single-cell RNA sequencing   machine learning   cellular heterogeneity  

Multimodal Learning Reveals Genotype–Phenotype Dynamics Background The complex relationship between genotype and phenotype has long been a central question in biology. Genotype refers to the genetic information of an organism, while phenotype is the manifestation of this genetic information in a specific environment. Although Wilhelm Johannsen intr...

Gene-Level Alignment of Single-Cell Trajectories

Medicine, Life Sciences, Cell Biology, Immunology, Genetics,
single-cell RNA sequencing   pseudotime trajectory inference   dynamic time warping   gene expression   cell state  

Gene-level Single-cell Trajectory Alignment: A New Method Based on Dynamic Programming The advent of single-cell RNA sequencing (scRNA-seq) technology has dramatically advanced biological research, enabling scientists to observe dynamic changes at the single-cell level over time and space. However, comparing such dynamics across samples or conditio...