Aberrant splicing exonizes C9orf72 repeat expansion in ALS/FTD

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
aberrant splicing   C9orf72   repeat expansion   ALS   frontotemporal dementia   DPR proteins   therapeutic targets  

New Pathway for ALS/FTD-Related C9orf72 Pathogenesis Revealed by Latest Nature Neuroscience Study Academic Background and Research Motivation Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are among the most challenging neurodegenerative diseases in clinical medicine, with complex pathogenesis that remains insufficiently expl...

Global Profiling of Alternative Splicing in Non-Small Cell Lung Cancer Reveals Novel Histological and Population Differences

Medicine, Oncology, Life Sciences, Biochemistry, Genetics,
non-small cell lung cancer   alternative splicing   population differences   tumor biology   biomarkers   molecular subtypes   therapeutic targets  

Global Profiling of Alternative Splicing in Non-Small Cell Lung Cancer Reveals Novel Histological and Population Differences Academic Background Lung cancer is one of the most frequently diagnosed cancers in the United States, with non-small cell lung cancer (NSCLC) accounting for the majority of cases. Among NSCLC, lung adenocarcinoma (LUAD) and l...