— Longitudinal Population Analysis Based on the “Pace of Aging” Method 1. Research Background and Scientific Significance With the acceleration of global population aging, objectively measuring and improving the health status of the elderly has become an important issue in social policy and public health worldwide. Traditionally, measurements of po...

1. Research Background and Academic Significance Alzheimer’s Disease (AD) is the most common form of dementia worldwide, accounting for about 60–80% of all dementia cases. The primary affected population is individuals over 65 years old, with characteristic pathological features including the deposition of amyloid-β plaques, neurofibrillary tangles...

Analysis of Large-Scale Network Study of the CSF Proteome in FTLD — Unlocking Molecular Signatures of Neurodegenerative Diseases I. Academic Background and Motivation Frontotemporal Lobar Degeneration (FTLD) is one of the most common causes of early-onset dementia (under age 65), triggering a range of progressive behavioral, language, and even moto...

Cervical Cancer (CC) is the fourth most common malignant tumor among women worldwide, particularly in low- and middle-income countries, where its incidence and mortality rates remain high. According to statistics, there were over 600,000 new cases and more than 340,000 deaths globally in 2020. The primary cause of cervical cancer is the persistent ...

Comprehensive Prediction and Analysis of Human Protein Essentiality Based on a Pretrained Large Language Model Academic Background Human Essential Proteins (HEPs) are crucial for individual survival and development. However, experimental methods for identifying HEPs are often costly, time-consuming, and labor-intensive. Additionally, existing compu...