Towards Cascading Genetic Risk in Alzheimer’s Disease

Medicine, Geriatrics, Neurology, Neurosurgery, Life Sciences, Biochemistry, Genetics,
Alzheimer’s disease   APOE   polygenic risk   longitudinal progression   biomarker  

Cascading Pattern in Genetic Risk Research for Alzheimer’s Disease Background and Research Motivation Alzheimer’s disease (AD) is a slowly progressing neurodegenerative disorder characterized by the accumulation of two pathological features: amyloid plaques and phosphorylated tau neurofibrillary tangles. These pathological features typically exist ...

Engineered Exosomes with a Photoinducible Protein Delivery System Enable CRISPR-Cas–Based Epigenome Editing in Alzheimer’s Disease

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
engineered exosomes   photoinducible protein   Alzheimer’s disease   CRISPR-Cas   epigenome editing   delivery system   memory improvement  

CRISPR-Cas-Based Epigenome Editing in Alzheimer’s Disease: Engineered Exosomes with a Photoinducible Protein Delivery System Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by progressive decline in cognitive function and memory, with currently limited treatment options. Genome editing technologies, such as ...

Astaxanthin Rescues Memory Impairments in Rats with Vascular Dementia by Protecting Against Neuronal Death in the Hippocampus

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
vascular dementia   astaxanthin   Alzheimer’s disease   neurodegenerative diseases   neuronal apoptosis  

Astaxanthin Protects Hippocampal Neurons Against Memory Impairment Caused by Vascular Dementia in Rats Background Introduction Vascular Dementia (VAD) is a progressive cognitive disorder caused by cerebrovascular disease leading to cognitive decline. Current research shows that chronic cerebral hypoperfusion (CCH) and insufficient blood supply are ...

Lycium Barbarum Polysaccharides Improves Cognitive Functions in ICV-STZ-Induced Alzheimer’s Disease Mice Model by Improving the Synaptic Structural Plasticity and Regulating IRS1/PI3K/AKT Signaling Pathway

Medicine, Medical Laboratory Science, Geriatrics, Neurology, Life Sciences, Biochemistry, Bioengineering, Immunology,
Alzheimer’s disease   ICV-STZ   insulin resistance   neurodegeneration   synapse  

Study on the Improvement of Cognitive Function in ICV-STZ-Induced Alzheimer’s Disease Mouse Model by Lycium Barbarum Polysaccharides Research Background Alzheimer’s disease (AD) is the most common neurodegenerative disease of the central nervous system, characterized by progressive cognitive impairment, memory loss, personality changes, and emotion...

Associations of CSF BACE1 with Amyloid Pathology, Neurodegeneration, and Cognition in Alzheimer’s Disease

Medicine, Basic Medical Sciences, Medical Laboratory Science, Neurology, Medical Imaging, Life Sciences,
Alzheimer’s disease   BACE1   PET imaging   neurodegeneration  

Original Title: 《Associations of CSF BACE1 with Amyloid Pathology, Neurodegeneration, and Cognition in Alzheimer’s Disease》 Background and Research Purpose Alzheimer’s Disease (AD) is a leading cause of dementia in the elderly, characterized by the accumulation of β-amyloid protein (Aβ) plaques in the brain. Beta-site APP cleaving enzyme 1 (BACE1) ...