Academic Background Neurodegenerative diseases, such as Parkinson’s disease (PD) and Alzheimer’s disease (AD), are often accompanied by abnormal aggregation and propagation of pathological proteins. The abnormal aggregation of α-synuclein is a central pathological feature of Parkinson’s disease and other synucleinopathies. Although extensive resear...

Academic Background Frontotemporal Dementia (FTD) is a group of progressive neurodegenerative diseases characterized primarily by behavioral changes, language impairment, or motor dysfunction. Although the incidence of FTD is lower than that of Alzheimer’s Disease (AD), it remains one of the leading causes of early-onset dementia. The molecular bas...

A Revolution in Optical Imaging: Development of a Multimodal Retinal Imaging System Combining OCT and Raman Spectroscopy Research Background and Significance Accessing molecular information of retinal tissue is pivotal for the early diagnosis of ophthalmic and neurodegenerative diseases. However, the current gold standard in retinal imaging—Optical...

Non-invasive Quantification of Cerebrospinal Fluid Dynamics and Ventricle-Subarachnoid Space Pressure Gradient Background Cerebrospinal fluid (CSF) is a vital component of the central nervous system, providing protection to brain tissue, maintaining intracranial pressure stability, and facilitating the clearance of metabolic waste. Abnormal CSF cir...

Astaxanthin Protects Hippocampal Neurons Against Memory Impairment Caused by Vascular Dementia in Rats Background Introduction Vascular Dementia (VAD) is a progressive cognitive disorder caused by cerebrovascular disease leading to cognitive decline. Current research shows that chronic cerebral hypoperfusion (CCH) and insufficient blood supply are ...