Critical Role of the Potential O-Linked Glycosylation Sites of CXCR4 in Cell Migration and Bone Marrow Homing of Hematopoietic Stem Progenitor Cells

Medicine, Basic Medical Sciences, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology,
CXCR4   O-linked glycosylation   hematopoietic stem progenitor cells   cell migration   bone marrow homing   glycosylation   CXCL12  

1. Academic Background and Research Origin Hematopoietic stem/progenitor cells (HSPCs) are the foundation for maintaining the steady state of the adult blood system. Every day, the human body needs to generate billions of new blood cells—a process that relies on the capacity of HSPCs for self-renewal and directed differentiation within the bone mar...

Diagnostic Accuracy and Value of CXCR4-Targeted PET/MRI Using 68Ga-Pentixafor for Tumor Localization in Cushing Disease

Medicine, Endocrinology, Neurosurgery, Medical Imaging,
Cushing Disease   68Ga-Pentixafor   PET/MRI   CXCR4   Tumor Localization   Diagnostic Accuracy   Pituitary Tumors  

Diagnostic Accuracy and Value of 68Ga-Pentixafor PET/MRI in Tumor Localization for Cushing’s Disease Academic Background Cushing’s disease is the primary cause of Cushing’s syndrome, characterized by excessive secretion of adrenocorticotropic hormone (ACTH) from the pituitary gland, often due to pituitary adenomas. Patients with chronic hypercortis...