Augmenting AMPA Receptor Signaling After Spinal Cord Injury Increases Ependymal-Derived Neural Stem/Progenitor Cell Migration and Promotes Functional Recovery

Medicine, Basic Medical Sciences, Neurology, Neurosurgery, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
spinal cord injury   ependymal cells   neural stem cells   AMPA receptors   cell migration   functional recovery  

Enhancement of AMPA Receptor Signaling After Spinal Cord Injury Promotes Ependymal-Derived Neural Stem/Progenitor Cell Migration and Functional Recovery —— Synopsis of the Latest Research in Nature Neuroscience 1. Academic Background: Challenges in Spinal Cord Injury Repair, Potential of Ependymal Cells, and Exploration of AMPA Receptor Mechanisms ...

Critical Role of the Potential O-Linked Glycosylation Sites of CXCR4 in Cell Migration and Bone Marrow Homing of Hematopoietic Stem Progenitor Cells

Medicine, Basic Medical Sciences, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology,
CXCR4   O-linked glycosylation   hematopoietic stem progenitor cells   cell migration   bone marrow homing   glycosylation   CXCL12  

1. Academic Background and Research Origin Hematopoietic stem/progenitor cells (HSPCs) are the foundation for maintaining the steady state of the adult blood system. Every day, the human body needs to generate billions of new blood cells—a process that relies on the capacity of HSPCs for self-renewal and directed differentiation within the bone mar...

Monocytes Use Protrusive Forces to Generate Migration Paths in Viscoelastic Collagen-Based Extracellular Matrices

Medicine, Oncology, Life Sciences, Cell Biology, Bioengineering, Immunology, Biophysics,
monocyte   cell migration   extracellular matrix   viscoelasticity   tumor microenvironment   collagen   protrusive force  

New Mechanism of Immune Cell Migration Revealed: How Monocytes “Pioneer Their Path” in the Tumor Microenvironment I. Academic Research Background and the Central Question Cell migration is a crucial biological process in life, encompassing embryonic development, tissue repair, immune responses, and the progression of various diseases. In the contex...

Growth Factor-Triggered De-Sialylation Controls Glycolipid-Lectin-Driven Endocytosis

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
de-sialylation   glycolipid-lectin   endocytosis   cell migration   cell adhesion   glycosylation   epidermal growth factor  

In cell biology, the glycosylation modification of cell surface glycoproteins plays a crucial role in processes such as cell signaling, adhesion, and migration. How dynamic changes in glycosylation regulate intracellular transport and function, particularly the internalization of cell surface receptors through endocytosis, remains an incompletely u...

Triple Knockdown of CD11a, CD49d, and PSGL1 in T Cells Reduces CAR-T Cell Toxicity but Preserves Activity Against Solid Tumors in Mice

Medicine, Oncology, Life Sciences, Cell Biology, Immunology,
CAR-T cells   solid tumors   immunotherapy   cell adhesion   cell migration  

Study on Reducing Toxicity of CAR-T Cell Therapy for Solid Tumors Academic Background Chimeric antigen receptor T-cell (CAR-T) therapy has made significant progress in treating hematologic malignancies, but its application in solid tumors faces major challenges. Solid tumors often lack tumor-specific antigens (TSAs), and CAR-T cells may attack norm...

Silencing of STEAP3 Suppresses Cervical Cancer Cell Proliferation and Migration via JAK/STAT3 Signaling Pathway

Medicine, Oncology,
STEAP3   cervical cancer   JAK/STAT3 signaling pathway   cell proliferation   cell migration   DNA methylation   iron metabolism  

The Role and Mechanism of STEAP3 in Cervical Cancer Background Cervical cancer (CC) is the fourth most common cancer among women globally, with approximately 600,000 new cases and 300,000 deaths annually. Although the five-year survival rate for early-stage cervical cancer patients exceeds 85% through treatments such as surgery, radiotherapy, and c...