Renal Protective Effects of Extracellular Vesicle-Encapsulated Tumor Necrosis Factor-α-Induced Protein 6 Derived from Mesenchymal Stem Cells

Medicine, Basic Medical Sciences, Nephrology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
mesenchymal stem cells   inflammation   renal protection   extracellular vesicles   TNF-α-induced protein 6   M2 macrophage polarization   regulatory T cells  

I. Research Background and Academic Significance In recent years, the incidence of acute kidney injury (AKI) has been continuously rising worldwide. AKI not only leads to acute loss of renal function but is increasingly recognized as being closely related to the occurrence and progression of chronic kidney disease (CKD). Numerous epidemiological an...

Targeting SRSF10 Might Inhibit M2 Macrophage Polarization and Potentiate Anti-PD-1 Therapy in Hepatocellular Carcinoma

Medicine, Hepatobiliary System, Oncology, Life Sciences, Immunology,
hepatocellular carcinoma   immune checkpoint blockade   SRSF10   lactate metabolism   M2 macrophage polarization   tumor microenvironment   glycolysis  

The Role of SRSF10 in Immunotherapy for Hepatocellular Carcinoma Academic Background Hepatocellular carcinoma (HCC) ranks sixth in global cancer incidence and third in mortality. Although surgical resection is the primary treatment for HCC, the high postoperative recurrence rate significantly impacts patient prognosis. In recent years, immunotherap...