Targeting the Chromatin Remodeler BAZ2B Mitigates Hepatic Senescence and MASH Fibrosis

Medicine, Hepatobiliary System, Geriatrics, Gastroenterology, Life Sciences, Cell Biology, Biochemistry, Genetics,
chromatin remodeling   BAZ2B   hepatic aging   MASH fibrosis   lipid metabolism   PPARα   epigenetic mechanism  

1. Research Background and Significance With global population aging on the rise, the incidence of metabolic dysfunction-associated steatohepatitis (MASH, also known as NASH) and related chronic liver diseases such as hepatic fibrosis is increasing year by year. These disorders have become a major focus and challenge in basic and clinical hepatolog...

Quasi-spatial single-cell transcriptomics based on physical tissue properties defines early aging-associated niche in liver

Medicine, Hepatobiliary System, Basic Medical Sciences, Geriatrics, Life Sciences, Cell Biology, Biochemistry, Immunology,
single-cell sequencing   fibrotic niche   liver aging   senescent cells   spatial omics   physical tissue properties  

Redefining the Early-Aging Microenvironment in the Liver: Quasi-spatial Single-cell Transcriptomics Reveals Fibrotic Niche Formation and Cellular Heterogeneity Background and Research Motivation Aging is an inevitable process in life, with one of its most significant features being the accumulation of senescent cells within tissues and organs. Thes...

Cox-SAGE: Enhancing Cox Proportional Hazards Model with Interpretable Graph Neural Networks for Cancer Prognosis

Information Science, Computer Science, Artificial Intelligence, Medicine, Hepatobiliary System, Oncology,
Cox proportional hazards model   cancer prognosis   graph neural networks   biomarker discovery   patient similarity graph  

1. Research Background and Disciplinary Frontiers Cancer prognosis analysis has always been a core research direction in the medical field. In recent years, with the widespread application of high-throughput sequencing technologies, scientists have been able to delve deeper into exploring molecular biomarkers and clinical characteristics of cancer ...

International Multicentre Validation of the Left Pancreatectomy Pancreatic Fistula Prediction Models and Development and Validation of the Combined DISPAIR-FRS Prediction Model

Medicine, Hepatobiliary System,
left pancreatectomy   pancreatic fistula   prediction models   multicentre study   DISPAIR-FRS   risk score   postoperative complications  

Academic Background Pancreatectomy is an important treatment for pancreatic diseases, but postoperative pancreatic fistula (POPF) is a common and serious complication, with an incidence rate as high as 20%. POPF not only prolongs hospital stays and increases medical costs but is also closely associated with increased postoperative mortality. Theref...

Preoperative Stereotactic Radiotherapy to Prevent Pancreatic Fistula in High-Risk Patients Undergoing Pancreatoduodenectomy (FIBROPANC): Prospective Multicentre Phase II Single-Arm Trial

Medicine, Hepatobiliary System, Anesthesiology, Gastroenterology, Oncology,
pancreatic fistula   stereotactic radiotherapy   pancreatoduodenectomy   high-risk patients   fibrosis   safety   efficacy  

Pancreaticoduodenectomy is a common surgery for treating tumors of the pancreas and surrounding organs, but postoperative pancreatic fistula (POPF) is one of its major complications, especially in high-risk patients, where the incidence of POPF can be as high as 50%. POPF not only increases hospitalization time and medical costs but can also lead t...