Randomized Explainable Machine Learning Models for Efficient Medical Diagnosis

Information Science, Computer Science, Artificial Intelligence, Medicine, Medical Laboratory Science, Urology, Nephrology, Medical Imaging, Oncology, Cardiovascular System,
medical diagnosis   randomized models   explainable artificial intelligence   extreme learning machines   random vector functional link   big data   deep learning  

New Breakthrough in Intelligent Medical Diagnosis: Randomized Explainable Machine Learning Models Drive Efficient Medical Diagnostics I. Academic Background and Research Motivation In recent years, Deep Learning (DL) models have played a crucial role in the field of healthcare. By processing vast amounts of medical data, DL significantly improves t...

Role of Recurrent Somatic Mutation and Progerin Expression in Early Vascular Aging of Chronic Kidney Disease

Medicine, Basic Medical Sciences, Geriatrics, Nephrology, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Genetics,
chronic kidney disease   vascular aging   somatic mutations   progerin   vascular smooth muscle cells   clonal expansion   molecular mechanisms  

1. Academic Background and Research Rationale Chronic Kidney Disease (CKD) is a global public health challenge. Epidemiological data indicate that CKD affects approximately 10–12% of the world’s population, acting as a major driver of cardiovascular disease (CVD) mortality worldwide. CKD patients often display “Early Vascular Aging” (EVA) phenomena...

Renal Protective Effects of Extracellular Vesicle-Encapsulated Tumor Necrosis Factor-α-Induced Protein 6 Derived from Mesenchymal Stem Cells

Medicine, Basic Medical Sciences, Nephrology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
mesenchymal stem cells   inflammation   renal protection   extracellular vesicles   TNF-α-induced protein 6   M2 macrophage polarization   regulatory T cells  

I. Research Background and Academic Significance In recent years, the incidence of acute kidney injury (AKI) has been continuously rising worldwide. AKI not only leads to acute loss of renal function but is increasingly recognized as being closely related to the occurrence and progression of chronic kidney disease (CKD). Numerous epidemiological an...

Pathogenic Variants in the Polycystin Pore Helix Cause Distinct Forms of Channel Dysfunction

Medicine, Basic Medical Sciences, Nephrology, Life Sciences, Cell Biology, Biochemistry, Genetics, Biophysics,
autosomal dominant polycystic kidney disease   polycystin   PKD2   ion channels   cryo-EM   channel dysfunction   protein assembly  

Molecular Mechanism Analysis of ADPKD Pathogenic Variants in Ion Channels – In-depth Interpretation of PNAS 2025 Latest Original Research I. Academic Research Background and Scientific Significance Autosomal Dominant Polycystic Kidney Disease (ADPKD) is one of the most common monogenic disorders worldwide, affecting millions of individuals. The pat...

Mechanistic Analysis of Channel Dysfunction Caused by Diverse Pathogenic Polycystin Pore Helix Variants

Medicine, Basic Medical Sciences, Nephrology, Life Sciences, Cell Biology, Biochemistry, Genetics, Biophysics,
autosomal dominant polycystic kidney disease   polycystin   channelopathy   ion channel   primary cilia   structure   drug development  

I. Research Background and Scientific Significance Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common monogenic hereditary kidney disease that affects millions of people worldwide. ADPKD is primarily caused by mutations in the renal polycystin family (especially the PKD1 and PKD2 genes), which encode channel subunits pivotal for ion c...