Exploring Diverse Approaches for Predicting Interferon-Gamma Release: Utilizing MHC Class II and Peptide Sequences

Information Science, Computer Science, Artificial Intelligence, Life Sciences, Biochemistry, Bioengineering, Immunology,
machine learning   T-cell response   immunology   predictive modeling   interferon-gamma   MHC class II   peptide sequences  

Academic Background and Research Significance In recent decades, therapeutic proteins have gained prominence as a research focus in the biopharmaceutical industry due to their huge potential in medicine. With their high targeting ability, therapeutic protein drugs are considered to offer solutions for many acute or chronic diseases (such as certain...

High-Throughput Discovery of MHC Class I- and II-Restricted T Cell Epitopes Using Synthetic Cellular Circuits

Medicine, Infectious Diseases, Rheumatology and Immunology, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Immunology,
high-throughput discovery   MHC class I   MHC class II   T cell epitopes   synthetic cellular circuits   antigen discovery  

High-Throughput Discovery of MHC Class I and II Restricted T Cell Epitopes Using a Novel Synthetic Cellular Circuit Research Background and Issues In recent years, antigen discovery technologies have made remarkable progress, especially in the application of human T-cell receptors (TCRs) in the recognition of major histocompatibility complex (MHC) ...