Oscillatory Contractile Forces Refine Endothelial Cell-Cell Interactions for Continuous Lumen Formation Governed by Heg1/CCM1

Medicine, Cardiovascular System, Life Sciences, Cell Biology, Biophysics,
oscillatory contractile forces   endothelial cells   Heg1   CCM1   lumen formation   cell-cell interactions   angiogenesis  

Academic Background The formation and maintenance of vascular networks are critical processes in embryonic development and tissue regeneration, involving the regulation of various biophysical forces. Endothelial cells (ECs) play a central role in angiogenesis and vasculogenesis, with the contractile forces of the cytoskeleton (actomyosin contractil...

Maternal Serum PLGF Associates with 3D Power Doppler Ultrasound Markers of Utero-Placental Vascular Development in the First Trimester: The Rotterdam Periconception Cohort

Medicine, Obstetrics and Gynecology,
placenta   angiogenesis   spiral artery remodeling   angiogenic factors   sFlt-1   preeclampsia  

Academic Background The placenta plays a critical role in health and disease during pregnancy, and its development and function directly impact pregnancy outcomes. The early development of the utero-placental vasculature is essential for ensuring normal placental function, while abnormal vascular development is closely associated with placenta-rela...

Enhanced Epithelial-Mesenchymal Transition Signatures Are Linked with Adverse Tumor Microenvironment, Angiogenesis, and Worse Survival in Gastric Cancer

Medicine, Gastroenterology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
epithelial-mesenchymal transition   gastric cancer   gene set variation analysis   survival rate   tumor microenvironment   angiogenesis  

Enhanced EMT Characteristics Associated with Unfavorable Tumor Microenvironment, Angiogenesis, and Poorer Prognosis in Gastric Cancer Academic Background Epithelial-Mesenchymal Transition (EMT) is an extremely important mechanism that promotes the metastasis of cancer cells. However, despite its apparent importance, the clinical significance of EMT...

Disturbance in Cerebral Blood Microcirculation and Hypoxic-Ischemic Microenvironment are Associated with the Development of Brain Metastasis

Medicine, Neurology, Neurosurgery, Oncology, Life Sciences, Immunology,
cerebral blood microcirculation   hypoxic-ischemic microenvironment   brain metastasis   angiogenesis   ANG-2   VEGF   anti-angiogenic therapy  

Microcirculatory Disorders of Cerebral Blood Flow and the Hypoxic-Ischemic Microenvironment Related to Brain Metastasis Development Background and Research Motivation Brain metastasis (BM) is an increasing challenge in oncology due to its severe impact on neurological function, limited treatment options, and resulting poor prognosis. BM develops th...