Molecular Mechanisms of Gut Microbiota and Its Metabolites Mediating Endothelial Cell Senescence During Aging – Interpretation of Latest Results from Nature Aging I. Research Background and Significance Against the backdrop of a deeply aging human society, cardiovascular disease (CVD) has become one of the greatest health threats to the global elde...

1. Research Background and Significance With global population aging on the rise, the incidence of metabolic dysfunction-associated steatohepatitis (MASH, also known as NASH) and related chronic liver diseases such as hepatic fibrosis is increasing year by year. These disorders have become a major focus and challenge in basic and clinical hepatolog...

I. Research Background The intestinal immune system must balance tolerance and defense against dietary antigens, microbiota-derived antigens, and self-antigens. Although CD4+ T cells are known to play a central role in gut immunity, how different antigen sources shape the composition of the T cell receptor (TCR) repertoire remains unclear. The trad...

Background Introduction Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide, with high incidence and mortality rates. According to statistics, approximately 1.87 million new cases of CRC were diagnosed globally in 2020, resulting in 915,000 deaths. Peritoneal metastasis (PM) is a common metastatic pathway of CRC, with about ...

Academic Background Ulcerative Colitis (UC) is a chronic inflammatory bowel disease characterized by recurrent inflammation and ulceration of the colonic mucosa. Current treatments for UC primarily rely on immunosuppressive drugs, such as corticosteroids, immunomodulators, and biologics. However, the immunosuppressive properties of these drugs incr...