Effectiveness of Chitosan Nanoparticles as a Radioprotective Agent Against Gamma-Induced Changes in the Histology and Biochemistry of Parotid Glands

Cancer is one of the leading causes of death worldwide. Radiotherapy, as a crucial method for cancer treatment, effectively kills cancer cells but also damages normal tissues, especially sensitive tissues such as salivary glands. The oxidative stress and inflammatory reactions induced by radiotherapy are the primary causes of salivary gland dysfunc...

Comparison of Long-Term Survival of Neoadjuvant Therapy Plus Surgery Versus Upfront Surgery and the Role of Adjuvant Therapy for T1b-2N0-1 Esophageal Cancer: A Population Study of the SEER Database and Chinese Cohort

Comparative Study on Treatment Strategies for Esophageal Cancer Academic Background Esophageal cancer is one of the digestive system tumors with high incidence and mortality rates worldwide, particularly in Asia, where the incidence of esophageal squamous cell carcinoma (SCC) is notably prominent. Although significant progress has been made in the ...

Evaluating the Effectiveness of Cytoreductive Surgery in Oligometastatic Prostate Cancer: Insights from Quantitative Analysis and Retrospective Cohort Studies

Evaluating the Effectiveness of Cytoreductive Surgery in Oligometastatic Prostate Cancer Academic Background Prostate cancer is the second most common malignancy among men globally, particularly in its advanced stages, where it is often accompanied by metastases, significantly impacting patients’ quality of life and prognosis. Oligometastatic prost...

Hepatic Arterial Infusion Chemotherapy-Based Conversion Hepatectomy in Responders Versus Nonresponders with Hepatocellular Carcinoma: A Multicenter Cohort Study

Hepatic Arterial Infusion Chemotherapy (HAIC)-Based Conversion Hepatectomy in Patients with Hepatocellular Carcinoma Academic Background Hepatocellular carcinoma (HCC) is one of the most common liver malignancies worldwide, particularly in China, where its incidence and mortality rates remain high. Despite advancements in treatment strategies, radi...

Contemporary Prognostic Signatures and Refined Risk Stratification of Gliomas: An Analysis of 4400 Tumors

Molecular Classification and Prognostic Features of Gliomas Background Introduction Glioma is the most common malignant brain tumor in adults, and its classification, risk stratification, and treatment standards have undergone significant changes in recent years. With the introduction of molecular markers, the classification system for gliomas has ...