ADSL-Generated Fumarate Binds and Inhibits STING to Promote Tumour Immune Evasion

Medicine, Oncology, Life Sciences, Cell Biology, Immunology,
tumour immune evasion   STING inhibition   ADSL   fumarate   breast cancer  

Research Background In the tumor microenvironment, highly aggressive tumors evade immune system attacks by suppressing the cGAS-STING signaling pathway. The cGAS-STING pathway is a critical mechanism for cells to sense cytoplasmic double-stranded DNA and initiate immune responses. cGAS (cyclic GMP-AMP synthase) catalyzes the production of cGAMP upo...

TP53-Specific Mutations Serve as a Potential Biomarker for Homologous Recombination Deficiency in Breast Cancer: A Clinical Next-Generation Sequencing Study

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
next-generation sequencing   homologous recombination deficiency   TP53   breast cancer   biomarker  

Breast cancer is one of the most common malignant tumors among women worldwide, with a complex pathogenesis involving multiple gene mutations and signaling pathway abnormalities. Homologous Recombination Deficiency (HRD) is a significant molecular characteristic in breast cancer, closely related to patients’ sensitivity to PARP inhibitor (PARPi) th...

Cell-Free Tumor DNA Analysis in Advanced or Metastatic Breast Cancer Patients: Mutation Frequencies, Testing Intention, and Clinical Impact

Medicine, Oncology,
cell-free tumor DNA   breast cancer   mutation frequencies   clinical impact   genetic testing  

Academic Background Breast cancer is one of the most common cancers among women worldwide, particularly advanced or metastatic breast cancer, which is challenging to treat and has a poor prognosis. With the development of precision medicine, the role of molecular biomarkers in breast cancer treatment has become increasingly prominent. Circulating t...

Deep Learning-Based Multi-Modal Data Integration Enhancing Breast Cancer Disease-Free Survival Prediction

Information Science, Computer Science, Artificial Intelligence, Medicine, Oncology,
breast cancer   multi-modality   deep learning   pathological   disease-free survival  

Breast cancer is one of the most common malignancies among women worldwide. Although early intervention and appropriate treatment have significantly improved patient survival rates, approximately 30% of cases still experience recurrence and distant metastasis, resulting in a 5-year survival rate of less than 23%. Traditional clinical prediction met...

Clinical and Patient-Reported Outcomes in Women Offered Oncoplastic Breast-Conserving Surgery as an Alternative to Mastectomy: ANTHEM Multicentre Prospective Cohort Study

Medicine, Oncology,
oncoplastic breast-conserving surgery   mastectomy   patient-reported outcomes   multicentre study   breast cancer  

Breast cancer is one of the most common cancers among women worldwide, with over 56,000 women diagnosed annually in the UK. Despite advancements in treatment, approximately 40% of patients still undergo mastectomy. While mastectomy effectively controls cancer, it profoundly impacts patients’ quality of life. Many women describe mastectomy as a “dis...