The Mevalonate Pathway Contributes to Breast Primary Tumorigenesis and Lung Metastasis

Medicine, Oncology,
mevalonate pathway   breast cancer   lung metastasis   Rho GTPases   cholesterol   gene expression   tumor recurrence  

Regulation of the Mevalonate Pathway in Breast Cancer and Its Role in Tumorigenesis and Lung Metastasis Background Introduction Breast cancer is one of the most common cancers among women worldwide, and its occurrence and metastasis mechanisms are complex, involving abnormal regulation of multiple signaling pathways and metabolic processes. In rece...

Dynamic Methylation and Expression of Alternative Promoters for Oestrogen Receptor Alpha in Cell Line Models of Fulvestrant Resistance

Medicine, Endocrinology, Oncology, Life Sciences, Biochemistry,
breast cancer   drug resistance   fulvestrant   methylation   oestrogen receptor   promoter  

Dynamic Changes in Estrogen Receptor Alpha (ERα) Promoter Methylation and Drug Resistance in Breast Cancer Cells Background Breast cancer is one of the most common cancers among women worldwide, with approximately 75% of breast cancer patients expressing estrogen receptor alpha (ERα, gene symbol ESR1). ERα is not only an important prognostic marker...

Targeting the ERK1/2 and p38 MAPK Pathways Attenuates Golgin-97 Depletion-Induced Cancer Progression in Breast Cancer

Medicine, Oncology, Life Sciences, Cell Biology, Immunology,
Golgi apparatus   Golgin-97   breast cancer   MAPK signaling   metastasis   inflammatory cytokine  

Targeting ERK1/2 and p38 MAPK Pathways Attenuates Golgin-97 Depletion-Induced Breast Cancer Progression Research Background Breast cancer is the most common type of cancer among women worldwide, with triple-negative breast cancer (TNBC) having a particularly high metastasis rate and poor prognosis. TNBC lacks expression of estrogen receptor, proges...

Analysis of HER2 Expression Changes from Breast Primary to Brain Metastases and the Impact of HER2-Low Expression on Overall Survival

Medicine, Neurosurgery, Oncology,
breast cancer   brain metastases   HER2 expression   survival analysis   noninvasive diagnostics  

HER2 Expression Dynamics in Breast Cancer Brain Metastases and Its Impact on Survival Background Breast cancer is one of the most common cancers among women worldwide, and brain metastases (BrMs) pose a significant challenge for patients. In recent years, with the prolonged survival of breast cancer patients, the incidence of brain metastases has g...

Association of CHEK2 Low-Risk Variants with Cancer Phenotypes

Medicine, Oncology, Life Sciences, Genetics,
CHEK2   low-risk variants   cancer phenotypes   breast cancer   genetic modifiers  

Association of CHEK2 Low-Risk Variants with Cancer Phenotypes Academic Background The CHEK2 gene (OMIM 604373) is one of the susceptibility genes for breast cancer. Monoallelic pathogenic variants (PVs) in CHEK2 are associated with an increased risk of breast, colorectal, kidney, and thyroid cancers. However, there is limited research on the phenot...