Microbiome Dysbiosis, Neutrophil Recruitment and Mesenchymal Transition of Mesothelial Cells Promotes Peritoneal Metastasis of Colorectal Cancer

Medicine, Gastroenterology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
microbiome dysbiosis   neutrophil recruitment   mesothelial cells   mesenchymal transition   colorectal cancer   peritoneal metastasis   tumor microenvironment  

Background Introduction Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide, with high incidence and mortality rates. According to statistics, approximately 1.87 million new cases of CRC were diagnosed globally in 2020, resulting in 915,000 deaths. Peritoneal metastasis (PM) is a common metastatic pathway of CRC, with about ...

Comparative Analysis of Tertiary Lymphoid Structures for Predicting Survival of Colorectal Cancer: A Whole-Slide Images-Based Study

Medicine, Oncology, Life Sciences, Immunology,
colorectal cancer   tertiary lymphoid structures   digital pathology   prognosis   immune  

Colorectal Cancer (CRC) is one of the most prevalent malignancies globally, with its prognosis closely related to immune responses within the tumor microenvironment. In recent years, Tertiary Lymphoid Structures (TLS), as an essential component of the tumor microenvironment, have been associated with favorable patient outcomes. TLS are aggregates o...

Polymorphic Single-Nucleotide Variants in miRNA Genes and the Susceptibility to Colorectal Cancer: Combined Evaluation by Pairwise and Network Meta-Analysis, Thakkinstian's Algorithm and FPRP Criterium

Medicine, Oncology, Life Sciences, Biochemistry, Genetics,
colorectal cancer   miRNA   single-nucleotide polymorphism   network meta-analysis   Thakkinstian's algorithm   false positive report probability   susceptibility  

Association Study of Polymorphic Single-Nucleotide Variants in miRNA Genes and Colorectal Cancer Susceptibility Academic Background Colorectal cancer (CRC) is one of the most common malignancies with high incidence and mortality rates worldwide. According to global cancer statistics in 2022, CRC ranks as the third most prevalent cancer, with over 1...

CYP19A1 Regulates Chemoresistance in Colorectal Cancer Through Modulation of Estrogen Biosynthesis and Mitochondrial Function

Medicine, Endocrinology, Gastroenterology, Oncology, Life Sciences, Biochemistry,
colorectal cancer   chemotherapy resistance   CYP19A1   mitochondria   mitochondrial respiratory chain complexes  

CYP19A1 Regulates Chemoresistance in Colorectal Cancer through Modulation of Estrogen Biosynthesis and Mitochondrial Function Background Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. Despite significant advances in early detection and treatment strategies, chemoresistance remains a major obstacle to eff...

FOXC1-Mediated Serine Metabolism Reprogramming Enhances Colorectal Cancer Growth and 5-FU Resistance

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry,
colorectal cancer   5-fluorouracil resistance   de novo serine synthesis   FOXC1   metabolic reprogramming  

FOXC1-Mediated Serine Metabolism Reprogramming Enhances Colorectal Cancer Growth and 5-FU Resistance Background Colorectal cancer (CRC) is the third most common cancer globally and the second leading cause of cancer-related deaths. Although surgical resection and adjuvant chemotherapy are the primary treatments for CRC, tumor development and chemot...