Mitochondria-Enriched Hematopoietic Stem Cells Exhibit Elevated Self-Renewal Capabilities Within the Context of Aged Bone Marrow

Medicine, Basic Medical Sciences, Geriatrics, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
hematopoietic stem cells   mitochondria   self-renewal   aging   bone marrow   single-cell analysis   cell differentiation  

Mitochondria-Enriched Hematopoietic Stem Cells Reveal Enhanced Self-Renewal Activity in Aged Bone Marrow: In-Depth Analysis of the Latest Study in Nature Aging I. Academic Background and Research Significance Hematopoietic stem cells (HSCs) are the essential foundation underlying life-long production of blood and immune cells. However, with aging, ...

Discovery of Large Extracellular Vesicles Blebbisomes and Their Functional Study

Medicine, Oncology, Life Sciences, Cell Biology, Immunology,
extracellular vesicles   Blebbisomes   intercellular communication   mitochondria   immune checkpoint proteins  

Academic Background Extracellular vesicles (EVs) are crucial mediators of intercellular communication, carrying proteins, lipids, and genetic information to participate in various physiological and pathological processes. However, our understanding of EVs remains incomplete, particularly regarding the study of exceptionally large EVs. To address th...

Mitochondria-Targeting Bimetallic Cluster Nanozymes Alleviate Neuropathic Pain through Scavenging ROS and Reducing Inflammation

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Neurology, Life Sciences, Cell Biology, Immunology,
mitochondria   anti-inflammation   neuropathic pain   reactive oxygen species   bimetallic nanozymes   oxidative stress   signaling pathways  

Mitochondria-Targeting Bimetallic Cluster Nanozymes Alleviate Neuropathic Pain by Scavenging ROS and Reducing Inflammation Background Introduction Neuropathic pain is a complex and multifaceted public health issue, with its high incidence and significant negative impact on patients’ quality of life making it a critical area of medical research. Cur...

CYP19A1 Regulates Chemoresistance in Colorectal Cancer Through Modulation of Estrogen Biosynthesis and Mitochondrial Function

Medicine, Endocrinology, Gastroenterology, Oncology, Life Sciences, Biochemistry,
colorectal cancer   chemotherapy resistance   CYP19A1   mitochondria   mitochondrial respiratory chain complexes  

CYP19A1 Regulates Chemoresistance in Colorectal Cancer through Modulation of Estrogen Biosynthesis and Mitochondrial Function Background Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. Despite significant advances in early detection and treatment strategies, chemoresistance remains a major obstacle to eff...

Regulation of Calcium Homeostasis in Endoplasmic Reticulum–Mitochondria Crosstalk: Implications for Skeletal Muscle Atrophy

Medicine, Anesthesiology, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Biophysics,
skeletal muscle   calcium   atrophy   mitochondria   endoplasmic reticulum   calcium homeostasis   muscle diseases  

The Critical Role of Calcium in Skeletal Muscle Function and Its Interaction with Mitochondria and the Endoplasmic Reticulum Academic Background Calcium ions (Ca²⁺) are crucial intracellular signaling molecules, particularly in the excitation-contraction coupling (ECC) of skeletal muscle. The contraction of skeletal muscle relies on the release and...