Mitochondria-Enriched Hematopoietic Stem Cells Reveal Enhanced Self-Renewal Activity in Aged Bone Marrow: In-Depth Analysis of the Latest Study in Nature Aging I. Academic Background and Research Significance Hematopoietic stem cells (HSCs) are the essential foundation underlying life-long production of blood and immune cells. However, with aging, ...
Academic Background Extracellular vesicles (EVs) are crucial mediators of intercellular communication, carrying proteins, lipids, and genetic information to participate in various physiological and pathological processes. However, our understanding of EVs remains incomplete, particularly regarding the study of exceptionally large EVs. To address th...
Mitochondria-Targeting Bimetallic Cluster Nanozymes Alleviate Neuropathic Pain by Scavenging ROS and Reducing Inflammation Background Introduction Neuropathic pain is a complex and multifaceted public health issue, with its high incidence and significant negative impact on patients’ quality of life making it a critical area of medical research. Cur...
CYP19A1 Regulates Chemoresistance in Colorectal Cancer through Modulation of Estrogen Biosynthesis and Mitochondrial Function Background Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. Despite significant advances in early detection and treatment strategies, chemoresistance remains a major obstacle to eff...
The Critical Role of Calcium in Skeletal Muscle Function and Its Interaction with Mitochondria and the Endoplasmic Reticulum Academic Background Calcium ions (Ca²⁺) are crucial intracellular signaling molecules, particularly in the excitation-contraction coupling (ECC) of skeletal muscle. The contraction of skeletal muscle relies on the release and...
Academic Background and Problem Statement Mitochondria, as crucial organelles in eukaryotic cells, are involved in cellular energy metabolism, signal transduction, and the regulation of cell survival and death. Mitochondrial dysfunction is associated with various human diseases, including neurodegenerative disorders, cardiovascular diseases, diabet...
Research Background The maintenance and repair of the hematopoietic system are crucial for the continuation of life and health in an organism. As the foundation of the hematopoietic system, the stability of hematopoietic stem cells (HSCs) is particularly important. The maintenance of the HSC pool relies on intrinsic and extrinsic factors, among whi...
Research Background and Objective As individuals age, hematopoietic stem cells (HSCs) progressively accumulate in the bone marrow, exhibiting metabolic resilience under various stress conditions. This metabolic resilience provides an aging advantage for HSCs, enabling them to maintain cell viability even under low metabolic conditions. Although agi...
MGA Deletion Promotes Richter’s Transformation by Regulating Mitochondrial Oxidative Phosphorylation This article mainly focuses on the transformation of chronic lymphocytic leukemia (CLL) into aggressive lymphoma, known as Richter’s Transformation (RT), exploring the function and molecular mechanism of MGA (MAX Gene Associated). MGA is a functiona...
Aging-induced trnaGlu-derived fragments disrupt glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization Academic Background Mitochondrial cristae are inward protrusions of the inner mitochondrial membrane that undergo significant morphological changes during aging. However, the molecular mechanisms leading to th...