NF-κB-Mediated Developmental Delay Extends Lifespan in Drosophila

1. Research Background Aging has long been viewed as a gradual decline in physiological function with age. However, mounting evidence indicates that developmental programs profoundly influence aging outcomes. For instance, developmental time (the time required for an organism to reach maturity) shows a significant positive correlation with adult li...

Loss-of-function variants in ERF are associated with a Noonan syndrome-like phenotype with or without craniosynostosis

Correlation between Erf Gene Loss-of-Function Variants and Noonan Syndrome-like Phenotype - With or Without Craniosynostosis Research Background Members of the ETS transcription factor family play a crucial role in RAS-MAPK signal transduction, regulating the expression of “early response” genes and other functionally related genes. Among them, ETS...