AV-FOS: Transformer-Based Audio-Visual Multimodal Interaction Style Recognition for Children with Autism Using the Revised Family Observation Schedule 3rd Edition (FOS-R-III)

Information Science, Computer Science, Artificial Intelligence, Medicine, Pediatrics, Psychiatry, Clinical Psychology, Medical Imaging,
autism spectrum disorder   challenging behaviors   multimodal learning   self-supervised learning   video understanding   interaction style recognition   clinical observation  

1. Background: Clinical Challenges and Technological Prospects in Behavior Monitoring of Children with Autism Autism Spectrum Disorder (ASD, autism) is a lifelong neurodevelopmental disorder. In recent years, the prevalence of autism in the United States has risen rapidly, with current epidemiological data indicating that one in every 36 children i...

RDGuru: A Conversational Intelligent Agent for Rare Diseases

Information Science, Artificial Intelligence, Medicine, Pediatrics, Basic Medical Sciences, Medical Laboratory Science, Life Sciences, Bioengineering, Genetics,
rare diseases   conversational AI   deep Q-network   medical consultation   large language model   knowledge Q&A   clinical decision-making  

Intelligent Conversational Agent for Rare Diseases—RDGuru: Cutting-edge Technology Powers a New Revolution in Clinical Diagnosis Academic Background and Research Motivation Rare Diseases (RD) refer to disease categories that affect fewer than 6.5 to 10 individuals per 10,000 population. Their individual rarity, complex clinical features, and divers...

Inflammatory Pathways and the Bone Marrow Microenvironment in Inherited Bone Marrow Failure Syndromes

Medicine, Pediatrics, Basic Medical Sciences, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
inherited bone marrow failure syndromes   inflammation   pro-inflammatory cytokines   bone marrow microenvironment   mesenchymal stromal cells   hematopoietic stem cells   cytokine network  

Inflammatory Pathways and Bone Marrow Microenvironment in Inherited Bone Marrow Failure Syndromes: New Insights into Chronic Inflammation Research Background and Academic Significance Inherited bone marrow failure syndromes (IBMFS) are a group of genetic disorders characterized by reduced hematopoietic cell production due to blood stem cell dysfunc...

Flash Radiation Reprograms Lipid Metabolism and Macrophage Immunity and Sensitizes Medulloblastoma to CAR-T Cell Therapy

Medicine, Pediatrics, Neurology, Neurosurgery, Oncology, Life Sciences, Immunology,
Flash radiation   Lipid metabolism   Macrophage   Medulloblastoma   CAR-T cell therapy   Immunosuppression   Tumor microenvironment  

Background Brain tumors, particularly medulloblastoma (MB) in children, are one of the leading causes of cancer-related deaths in pediatric populations. Despite advancements in treatments such as surgical resection, radiotherapy, and chemotherapy, the prognosis for high-risk MB remains poor. In recent years, immunotherapy, especially CAR-T cell the...

Targeting ESM1 via SOX4 Promotes the Progression of Infantile Hemangioma through the PI3K/AKT Signaling Pathway

Medicine, Pediatrics, Oncology, Life Sciences, Immunology,
infantile hemangioma   CD31+ HEMECs   SOX4   proliferation   angiogenesis  

Infantile Hemangioma (IH) is the most common benign vascular tumor in children, with an incidence rate of approximately 4%-10%. Although most IH cases resolve spontaneously, some cases may lead to permanent pigmentation, fibrous tissue accumulation, and scarring, affecting the appearance and quality of life of children. Additionally, certain IH cas...