Embryonic Motor Neuron Programming Factors Reactivate Immature Gene Expression and Suppress ALS Pathologies in Postnatal Motor Neurons

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
motor neuron   ALS   transcription factors   gene expression   neurodegeneration   reprogramming   gene therapy  

1. Academic Background and Research Motivation Degenerative diseases of motor neurons, such as Amyotrophic Lateral Sclerosis (ALS), have long been a key research area in neuroscience. ALS is characterized by adult onset, with progressive degeneration of motor neurons leading to paralysis and death. In diseases such as ALS, aging is considered a maj...

The Discharge Characteristics of Motor Units Innervating Functionally Paralyzed Muscles

Medicine, Neurology,
spinal cord injury   motor neuron   high-density surface electromyography   motor unit   neural plasticity  

Study on the Discharge Characteristics of Motor Neurons Innervating Paralyzed Muscles after Spinal Cord Injury Academic Background Spinal Cord Injury (SCI) is a severe neurological injury that typically leads to the loss of motor and sensory functions below the injury level. Although patients clinically diagnosed with complete SCI are considered un...