1. Research Background and Scientific Problem The health of the hematopoietic system is crucial to the proper functioning of the body, with hematopoietic stem cells (HSCs) at its core in maintaining normal blood system operation. HSCs possess self-renewal and multipotent differentiation abilities, capable of generating all types of blood cells, inc...

Background Introduction In cell biology, understanding how cells respond differently to perturbations is crucial. Perturbation refers to altering cell states through gene editing, chemical substances, environmental changes, or mechanical forces to study their functions. However, existing methods have limitations in quantifying heterogeneous respons...

The advent of single-cell RNA sequencing (scRNA-seq) technology has provided unprecedented resolution for studying gene expression dynamics during cell development and differentiation. However, due to the complexity of biological processes, cell developmental trajectories under different conditions are often asymmetric, posing challenges for data i...

S-nitrosylation of CRTC1 in Alzheimer’s Disease Impairs CREB-dependent Gene Expression Induced by Neuronal Activity Academic Background Alzheimer’s disease (AD) is a common neurodegenerative disorder characterized by the gradual loss of memory and cognitive function. The pathological mechanisms of AD are complex, involving various molecular and cel...

Single-Cell Analysis Reveals Common Features of Neuroinflammation in Cerebrospinal Fluid Neuroinflammation is a core pathological feature of neurological diseases, involving complex interactions between the cerebrospinal fluid (CSF) and the peripheral immune system. Although previous studies have revealed the clonal expansion of lymphocytes in the ...