Embryonic Motor Neuron Programming Factors Reactivate Immature Gene Expression and Suppress ALS Pathologies in Postnatal Motor Neurons

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
motor neuron   ALS   transcription factors   gene expression   neurodegeneration   reprogramming   gene therapy  

1. Academic Background and Research Motivation Degenerative diseases of motor neurons, such as Amyotrophic Lateral Sclerosis (ALS), have long been a key research area in neuroscience. ALS is characterized by adult onset, with progressive degeneration of motor neurons leading to paralysis and death. In diseases such as ALS, aging is considered a maj...

Aberrant Engagement of P-selectin Drives Hematopoietic Stem Cell Aging in Mice

Medicine, Basic Medical Sciences, Geriatrics, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology,
P-selectin   hematopoietic stem cells   aging   gene expression   erythropoiesis   inflammation   stem cell regeneration  

1. Research Background and Scientific Problem The health of the hematopoietic system is crucial to the proper functioning of the body, with hematopoietic stem cells (HSCs) at its core in maintaining normal blood system operation. HSCs possess self-renewal and multipotent differentiation abilities, capable of generating all types of blood cells, inc...

Decoding Heterogeneous Single-Cell Perturbation Responses

Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
single-cell perturbation   gene expression   cellular response   transcriptomics   CRISPR  

Background Introduction In cell biology, understanding how cells respond differently to perturbations is crucial. Perturbation refers to altering cell states through gene editing, chemical substances, environmental changes, or mechanical forces to study their functions. However, existing methods have limitations in quantifying heterogeneous respons...

Trajectory Alignment of Gene Expression Dynamics

Medicine, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology, Genetics, Microbiology,
gene expression   single-cell transcriptomics   trajectory alignment   bioinformatics   differentially expressed genes  

The advent of single-cell RNA sequencing (scRNA-seq) technology has provided unprecedented resolution for studying gene expression dynamics during cell development and differentiation. However, due to the complexity of biological processes, cell developmental trajectories under different conditions are often asymmetric, posing challenges for data i...

S-Nitrosylation of CRTC1 in Alzheimer’s Disease Impairs CREB-Dependent Gene Expression Induced by Neuronal Activity

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry,
Alzheimer’s disease   CRTC1   S-nitrosylation   CREB   gene expression  

S-nitrosylation of CRTC1 in Alzheimer’s Disease Impairs CREB-dependent Gene Expression Induced by Neuronal Activity Academic Background Alzheimer’s disease (AD) is a common neurodegenerative disorder characterized by the gradual loss of memory and cognitive function. The pathological mechanisms of AD are complex, involving various molecular and cel...

Single-cell analysis of cerebrospinal fluid reveals common features of neuroinflammation

Medicine, Infectious Diseases, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
single-cell analysis   neuroinflammation   cerebrospinal fluid   gene expression   immune cells   multiple sclerosis   lymphocyte clonal expansion  

Single-Cell Analysis Reveals Common Features of Neuroinflammation in Cerebrospinal Fluid Neuroinflammation is a core pathological feature of neurological diseases, involving complex interactions between the cerebrospinal fluid (CSF) and the peripheral immune system. Although previous studies have revealed the clonal expansion of lymphocytes in the ...