Embryonic Motor Neuron Programming Factors Reactivate Immature Gene Expression and Suppress ALS Pathologies in Postnatal Motor Neurons

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
motor neuron   ALS   transcription factors   gene expression   neurodegeneration   reprogramming   gene therapy  

1. Academic Background and Research Motivation Degenerative diseases of motor neurons, such as Amyotrophic Lateral Sclerosis (ALS), have long been a key research area in neuroscience. ALS is characterized by adult onset, with progressive degeneration of motor neurons leading to paralysis and death. In diseases such as ALS, aging is considered a maj...

Multiscale Footprints Reveal the Organization of Cis-Regulatory Elements

Information Science, Artificial Intelligence, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
cis-regulatory elements   chromatin accessibility   transcription factors   deep learning   single-cell sequencing   genomics   cell differentiation  

Multiscale Footprints Reveal the Role of Cis-Regulatory Elements in Cell Differentiation and Aging Background Introduction The regulation of gene expression is a key mechanism in cell fate determination and disease development, and cis-regulatory elements (CREs) play a crucial role in this process. CREs dynamically regulate gene expression by bindi...

Genome-Wide Single-Cell and Single-Molecule Footprinting of Transcription Factors with Deaminase

Life Sciences, Cell Biology, Biochemistry, Genetics,
transcription factors   deaminase   single-molecule sequencing   single-cell genomics   TF binding cooperativity  

Genome-Wide Single-Cell and Single-Molecule Footprinting of Transcription Factors with Deaminase Academic Background In humans and other mammals, although the genome of each somatic cell is essentially the same, the functions of different cell types vary significantly. This diversity is primarily determined by the binding of transcription factors (...

ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis

Medicine, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
ARID1A   SWI/SNF   transcription factors   memory B cells   lymphoma   chromatin remodeling   cancer  

ARID1A Loss and B Cell Fate and Lymphoma Occurrence Background Introduction This paper investigates the critical role of ARID1A (AT-Rich Interactive Domain 1A) in B cell fate determination and lymphoma occurrence. ARID1A is an important subunit of the BRG1/Brahma-associated factors (BAF) complex, with mutations commonly found in various human malig...