Augmenting AMPA Receptor Signaling After Spinal Cord Injury Increases Ependymal-Derived Neural Stem/Progenitor Cell Migration and Promotes Functional Recovery

Enhancement of AMPA Receptor Signaling After Spinal Cord Injury Promotes Ependymal-Derived Neural Stem/Progenitor Cell Migration and Functional Recovery —— Synopsis of the Latest Research in Nature Neuroscience 1. Academic Background: Challenges in Spinal Cord Injury Repair, Potential of Ependymal Cells, and Exploration of AMPA Receptor Mechanisms ...

The Discharge Characteristics of Motor Units Innervating Functionally Paralyzed Muscles

Study on the Discharge Characteristics of Motor Neurons Innervating Paralyzed Muscles after Spinal Cord Injury Academic Background Spinal Cord Injury (SCI) is a severe neurological injury that typically leads to the loss of motor and sensory functions below the injury level. Although patients clinically diagnosed with complete SCI are considered un...

Photocrosslinkable Human Amniotic Membrane Hydrogel for Recovery from Spinal Cord Injury

Photocrosslinked Human Amniotic Membrane Hydrogel for Spinal Cord Injury Repair Academic Background Spinal Cord Injury (SCI) is a severe neurological disorder that often leads to loss of motor function and a decline in the quality of life for patients. Despite significant advancements in tissue engineering and regenerative medicine in recent years,...

The Discharge Characteristics of Motor Units Innervating Functionally Paralyzed Muscles

Functional Study of Motor Neurons After Spinal Cord Injury Background Introduction Spinal Cord Injury (SCI) is a severe neurological disorder that often leads to the loss of motor function in patients. Although patients may lose voluntary control of limb movements after SCI, studies have shown that motor neurons below the injury level may still ret...

A Glucocorticoid Spike Derails Muscle Repair to Heterotopic Ossification After Spinal Cord Injury

A Glucocorticoid Spike Derails Muscle Repair to Heterotopic Ossification After Spinal Cord Injury

Academic Background and Problem Statement Neurogenic Heterotopic Ossification (NHO) is a pathological condition where ectopic bone tissue forms in muscles following severe central nervous system (CNS) injuries, such as spinal cord injury (SCI), traumatic brain injury (TBI), or stroke. NHO not only impairs motor function but can also lead to joint s...

MERTK Reduces Blood-Spinal Cord Barrier Permeability Through the RhoA/ROCK1/P-MLC Pathway After Spinal Cord Injury

Study on MERTK Reducing Blood-Spinal Cord Barrier Permeability after Spinal Cord Injury via RhoA/ROCK1/p-MLC Pathway Spinal Cord Injury (SCI) is a central nervous system disease caused by trauma, inflammation, tumors, or other pathological reasons, resulting in sensory, motor, and autonomic nervous system dysfunction in patients, imposing a heavy b...