Single-cell and spatial transcriptomics reveal divergent microenvironments and progression signatures in early- and late-onset prostate cancer

Medicine, Basic Medical Sciences, Geriatrics, Urology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
single-cell sequencing   spatial transcriptomics   prostate cancer   heterogeneity   tumor microenvironment   androgen response   tumor progression  

Background: Age-related Heterogeneity in Prostate Cancer and New Opportunities for Precision Medicine Prostate cancer (PCA) is the second most common malignancy and the fifth leading cause of cancer-related death among men worldwide. With the global aging population and the advancement of health screening, the age of onset for prostate cancer has b...

PRMT5-mediated arginine methylation stabilizes GPX4 to suppress ferroptosis in cancer

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry,
ferroptosis   PRMT5   GPX4   cancer therapy   methylation   tumor progression   antioxidant  

Background Introduction Ferroptosis is a form of cell death triggered by iron-dependent lipid peroxidation, which has recently been recognized as having significant potential in cancer therapy. Cancer cells evade ferroptosis through various molecular alterations and metabolic reprogramming mechanisms, with glutathione peroxidase 4 (GPX4) being a ke...

SPTLC2 Drives an EGFR-FAK-HBEGF Signaling Axis to Promote Ovarian Cancer Progression

Medicine, Obstetrics and Gynecology, Oncology,
ovarian cancer   EGFR signaling pathway   SPTLC2   tumor progression   metastasis   therapeutic target   cell proliferation  

SPTLC2 Drives an EGFR-FAK-HBEGF Signaling Axis to Promote Ovarian Cancer Progression Academic Background Ovarian cancer (OC) is one of the most lethal cancers in the female reproductive system, with complex pathogenesis and limited treatment options. The epidermal growth factor receptor (EGFR) signaling pathway is widely dysregulated in various can...