Background: Age-related Heterogeneity in Prostate Cancer and New Opportunities for Precision Medicine Prostate cancer (PCA) is the second most common malignancy and the fifth leading cause of cancer-related death among men worldwide. With the global aging population and the advancement of health screening, the age of onset for prostate cancer has b...
Research Background Vascular system development is a highly precise regulatory process involving two key stages: vasculogenesis and angiogenesis. Although the VEGF (vascular endothelial growth factor) and Wnt signaling pathways have been confirmed to regulate vascular development in the peripheral and central nervous systems (CNS), respectively, th...
Spatial Transcriptomics: Cutting-Edge Technology for Deciphering Spatial Heterogeneity in Tissues Spatial transcriptomics (ST) is an emerging sequencing technology that has rapidly developed in recent years. Its core advantage lies in the simultaneous acquisition of gene expression and spatial location information at the tissue section level, provi...
A New Method for Scalable Spatial Transcriptomics via Large-Format Microarrays: The Birth of Array-Seq Technology Background and Research Motivation In recent years, spatiomolecular analyses have become pivotal tools in biomedical research and clinical pathology due to their ability to study how the spatial organization of cells and molecules withi...
Single-Cell and Spatial Transcriptomics Study of Meningeal Solitary Fibrous Tumors Academic Background Meningeal Solitary Fibrous Tumors (SFTs) are rare mesenchymal tumors originating from the meninges of the central nervous system (CNS). Although SFTs are histologically similar to other meningeal tumors (such as meningiomas), their unique clinical...
Spatial Transcriptomic Clocks Reveal Cell Proximity Effects in Brain Aging Academic Background With aging, cognitive function declines, and the risk of neurodegenerative diseases significantly increases. Brain aging is a complex process accompanied by numerous cellular changes. However, how aging cells affect neighboring cells and how this contribu...
Study on Mouse Sepsis-Associated Encephalopathy Based on Single Cell and Spatial Transcriptomics Background Organ dysfunction leading to death in sepsis is related to an imbalance in the host’s response to infection, and it has a high global mortality rate. Recent studies have shown that sepsis can cause brain dysfunction, known as sepsis-associate...
Research Report on Spatiotemporal Transcriptomic Changes in Human Ovarian Aging and the Regulatory Role of FOXP1 Academic Background With the continuous increase in global average life expectancy, health issues faced by women during menopause are receiving increasing attention. Ovarian aging is one of the significant issues, closely related to vari...
Spatial Enrichment and Genomic Analysis Reveal Association between NOMO1 and Amyotrophic Lateral Sclerosis Introduction Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease in which motor neurons in the brain and spinal cord gradually degrade. Although the genetic susceptibility of sporadic ALS patients remains uncertain, TDP-4...