Single-cell and spatial transcriptomics reveal divergent microenvironments and progression signatures in early- and late-onset prostate cancer

Medicine, Basic Medical Sciences, Geriatrics, Urology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
single-cell sequencing   spatial transcriptomics   prostate cancer   heterogeneity   tumor microenvironment   androgen response   tumor progression  

Background: Age-related Heterogeneity in Prostate Cancer and New Opportunities for Precision Medicine Prostate cancer (PCA) is the second most common malignancy and the fifth leading cause of cancer-related death among men worldwide. With the global aging population and the advancement of health screening, the age of onset for prostate cancer has b...

Site-Specific Genetic and Functional Signatures of Aortic Endothelial Cells at Aneurysm Predilection Sites in Healthy and AngII ApoE−/− Mice

Medicine, Cardiovascular System,
aortic aneurysm   endothelial cells   heterogeneity   site-specificity   RNA-seq  

Site-Specific Genetic and Functional Signatures of Aortic Endothelial Cells at Aneurysm Predilection Sites in Healthy and AngII ApoE−/− Mice Academic Background Aortic aneurysm (AA) is characterized by pathological dilation at specific predilection sites of the vessel, potentially leading to life-threatening vascular rupture. Aortic aneurysms typic...

MALDI Imaging Combined with Two-Photon Microscopy Reveals Local Differences in the Heterogeneity of Colorectal Cancer

MALDI Imaging Combined with Two-Photon Microscopy Reveals Local Differences in the Heterogeneity of Colorectal Cancer

Medicine, Medical Laboratory Science, Medical Imaging, Oncology,
colorectal cancer   tumor microenvironment   collagen fibers   two-photon microscopy   MALDI imaging   proteomics   heterogeneity  

Multimodal Imaging Study of the Tumor Microenvironment in Colorectal Cancer: Revealing Spatial Heterogeneity Academic Background Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide, with its complexity and heterogeneity posing significant challenges for treatment and prognosis prediction. The tumor microe...

Life History Dynamics of Evolving Tumors: Insights into Task Specialization, Trade-offs, and Tumor Heterogeneity

Medicine, Oncology, Life Sciences, Cell Biology, Immunology, Genetics,
tumor evolution   task specialization   heterogeneity   trade-offs   tumor microenvironment  

Cancer Cell International - Review Report Background and Motivation In recent decades, research into cancer evolution has gradually revealed that the evolutionary patterns of cancer cells share many similarities with species evolution. This notion has changed our understanding of tumor evolution and heterogeneity. Cancer is initiated by the mutatio...