Multi-scale and Multi-level Feature Assessment Framework for Classification of Parkinson’s Disease State from Short-term Motor Tasks

Information Science, Artificial Intelligence, Medicine, Neurology, Life Sciences, Bioengineering,
Parkinson’s disease   feature assessment   machine learning   wearable devices   short-term motor tasks  

Academic Background Parkinson’s Disease (PD) is the second most common chronic neurodegenerative disease, primarily affecting individuals aged 65 and above. With the global population aging, the prevalence of Parkinson’s disease is projected to increase from 7 million in 2015 to 13 million by 2040. Currently, the diagnosis of Parkinson’s disease ma...

Transmission of Peripheral Blood α-Synuclein Fibrils Exacerbates Synucleinopathy and Neurodegeneration in Parkinson’s Disease by Endothelial LAG3 Endocytosis

Medicine, Neurology, Life Sciences, Cell Biology, Immunology,
α-synuclein fibrils   Parkinson’s disease   LAG3 endocytosis   peripheral blood transmission   neurodegeneration  

Transmission of Peripheral Blood α-Synuclein Fibrils Exacerbates Synucleinopathy and Neurodegeneration in Parkinson’s Disease via Endothelial LAG3 Endocytosis Academic Background Parkinson’s disease (PD) is an age-related neurodegenerative disorder characterized by the abnormal formation and transmission of α-synuclein (α-syn). Recent studies have ...

Propagation of Pathologic α-Synuclein from Kidney to Brain May Contribute to Parkinson’s Disease

Medicine, Urology, Nephrology, Neurology, Life Sciences,
Parkinson’s disease   α-synuclein   renal function   pathologic propagation   neurodegenerative disorders  

Pathological Link Between Kidney Disease and Parkinson’s Disease Academic Background Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by the abnormal aggregation of α-synuclein (α-syn) in the brain, forming Lewy bodies (LBs) and Lewy neurites (LNs). In recent years, increasing evidence suggests that the pathological agg...

Electroacupuncture Ameliorated Locomotor Symptoms in MPTP-Induced Mice Model of Parkinson’s Disease by Regulating Autophagy via Nrf2 Signaling

Medicine, Neurology,
Electroacupuncture   Autophagy   Nrf2 signaling   Parkinson’s disease   Neuroprotection   Motor function  

Study on Electroacupuncture Improving Parkinson’s Disease Symptoms by Regulating Autophagy Academic Background Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide, primarily characterized by the gradual loss of dopamine (DA) neurons in the substantia nigra of the midbrain and the abnormal accumulation of α-synucle...

Amelioration of astrocyte-mediated neuroinflammation by EI-16004 confers neuroprotection in an MPTP-induced Parkinson’s disease model

Medicine, Neurology, Pharmacy, Life Sciences, Cell Biology, Biochemistry,
Parkinson’s disease   EI-16004   1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine   neuroprotection   neuroinflammation   astrocyte  

Alleviating Effect of EI-16004 on Astrocyte-Mediated Neuroinflammation in MPTP-Induced Parkinson’s Disease Model Background Introduction Parkinson’s Disease (PD) is a neurodegenerative disorder primarily affecting the elderly, characterized by tremors, bradykinesia, rigidity, and loss of postural reflexes, mainly due to the loss of dopaminergic neu...