Activation of AMPK by GLP-1R Agonists Mitigates Alzheimer-Related Phenotypes in Transgenic Mice

Medicine, Basic Medical Sciences, Geriatrics, Endocrinology, Neurology, Life Sciences, Cell Biology, Biochemistry,
GLP-1R agonists   AMPK   Alzheimer's disease   transgenic mice   neuroprotection   amyloid-beta   diabetes  

I. Research Background and Scientific Question Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide, with pathological features mainly including neuronal loss, neurofibrillary tangles, and senile plaques (mainly formed by amyloid-β [Aβ] deposition). According to statistics, the number of AD patients continues to rise each...

Relaxin-2 Attenuates Oxidative Stress and Neuronal Apoptosis via the ERK-nNOS-NO Pathway After Germinal Matrix Hemorrhage in Rats

Medicine, Neurology, Neurosurgery,
oxidative stress   neuronal apoptosis   relaxin-2   ERK-nNOS-NO pathway   germinal matrix hemorrhage   rat model   neuroprotection  

rh-relaxin-2 Attenuates Oxidative Stress and Neuronal Apoptosis via the ERK-nNOS-NO Pathway After Germinal Matrix Hemorrhage in Rats Academic Background Germinal Matrix Hemorrhage (GMH) is one of the most common neurological disorders in newborns, particularly in preterm infants, and is a major cause of brain injury. GMH not only triggers acute inf...

FBXL16: A New Regulator of Neuroinflammation and Cognition in Alzheimer’s Disease through the Ubiquitination-Dependent Degradation of Amyloid Precursor Protein

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
FBXL16   ubiquitination   Alzheimer’s disease   neuroprotection   amyloid precursor protein  

FBXL16: A New Regulator of Neuroinflammation and Cognition in Alzheimer’s Disease through Ubiquitination-Dependent Degradation of Amyloid Precursor Protein Academic Background Alzheimer’s Disease (AD) is an age-related neurodegenerative disorder characterized by progressive cognitive decline. With the global aging population, the incidence of neuro...

Neuroprotection with Glyceryl Trinitrate Post-Endovascular Therapy in Acute Ischemic Stroke: A Pilot Randomized Controlled Trial

Medicine, Infectious Diseases, Basic Medical Sciences, Emergency Medicine, Neurology, Cardiovascular System, Life Sciences, Biochemistry,
acute ischemic stroke   glyceryl trinitrate   endovascular therapy   neuroprotection   randomized controlled trial  

Overview of Nitroglycerin-Based Neuroprotection in Acute Ischemic Stroke: A Pilot Randomized Controlled Trial Review Background and Research Objectives Acute ischemic stroke (AIS) is one of the leading global causes of disability and death. Despite the significant improvement in vascular recanalization rates and patient outcomes achieved with moder...

Amelioration of astrocyte-mediated neuroinflammation by EI-16004 confers neuroprotection in an MPTP-induced Parkinson’s disease model

Medicine, Neurology, Pharmacy, Life Sciences, Cell Biology, Biochemistry,
Parkinson’s disease   EI-16004   1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine   neuroprotection   neuroinflammation   astrocyte  

Alleviating Effect of EI-16004 on Astrocyte-Mediated Neuroinflammation in MPTP-Induced Parkinson’s Disease Model Background Introduction Parkinson’s Disease (PD) is a neurodegenerative disorder primarily affecting the elderly, characterized by tremors, bradykinesia, rigidity, and loss of postural reflexes, mainly due to the loss of dopaminergic neu...