Targeting the Chromatin Remodeler BAZ2B Mitigates Hepatic Senescence and MASH Fibrosis

Medicine, Hepatobiliary System, Geriatrics, Gastroenterology, Life Sciences, Cell Biology, Biochemistry, Genetics,
chromatin remodeling   BAZ2B   hepatic aging   MASH fibrosis   lipid metabolism   PPARα   epigenetic mechanism  

1. Research Background and Significance With global population aging on the rise, the incidence of metabolic dysfunction-associated steatohepatitis (MASH, also known as NASH) and related chronic liver diseases such as hepatic fibrosis is increasing year by year. These disorders have become a major focus and challenge in basic and clinical hepatolog...

ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis

Medicine, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
ARID1A   SWI/SNF   transcription factors   memory B cells   lymphoma   chromatin remodeling   cancer  

ARID1A Loss and B Cell Fate and Lymphoma Occurrence Background Introduction This paper investigates the critical role of ARID1A (AT-Rich Interactive Domain 1A) in B cell fate determination and lymphoma occurrence. ARID1A is an important subunit of the BRG1/Brahma-associated factors (BAF) complex, with mutations commonly found in various human malig...