T-cell receptors (TCRs) play a crucial role in the adaptive immune system by recognizing pathogens through binding to specific antigen epitopes. Understanding the interactions between TCRs and epitopes is essential for uncovering the biological mechanisms of immune responses and developing T cell-mediated immunotherapies. However, although the impo...

The Impact of a Whole Food, Plant-Based Diet on Amino Acid Levels in Patients with Metastatic Breast Cancer Research Background The growth and survival of cancer cells depend on significant metabolic demands, particularly for amino acids. Tumors meet these demands by acquiring amino acids from the surrounding microenvironment, and dietary amino aci...

The Role of Brain Barriers in Brain Metastasis Background Introduction Brain metastases (BMs) are the most common intracranial tumors in adults, occurring 3 to 10 times more frequently than primary brain tumors. Despite multimodal treatments including surgical resection, radiotherapy, and chemotherapy, the prognosis for brain metastases remains poo...

Signal Integrator Function of CXXC5 in Cancer Academic Background CXXC5 (CXXC-type zinc finger protein 5) is a member of the ZF-CXXC protein family and plays a pivotal role in signal integration and information transfer within the cellular signaling network. By regulating multiple signaling pathways (such as Wnt/β-catenin, TGF-β/BMP, ATM/p53, etc.)...

The Incidence, Risk Factors, and Prognostic Impact of Bleeding Risk in Cancer Patients: A Review of the Vienna Cancer, Thrombosis, and Bleeding Study Academic Background and Research Motivation Cancer patients frequently experience hemostatic dysregulation, yet existing research has primarily focused on cancer-associated venous thromboembolism (VTE...