A Hierarchy of Intestinal Antigens Instructs the CD4+ T Cell Receptor Repertoire

I. Research Background The intestinal immune system must balance tolerance and defense against dietary antigens, microbiota-derived antigens, and self-antigens. Although CD4+ T cells are known to play a central role in gut immunity, how different antigen sources shape the composition of the T cell receptor (TCR) repertoire remains unclear. The trad...

High Sensitivity of Shotgun Metagenomic Sequencing in Colon Tissue Biopsy by Host DNA Depletion

High sensitivity of high-throughput metagenomic sequencing in colon tissue biopsies: Eliminating the impact of host DNA Background Evaluating bacterial taxonomic structure through next-generation sequencing without culturing has become a common method for studying the relationship between bacterial imbalance and various diseases. Previous studies h...

Targeting the Intestinal Circadian Clock by Meal Timing Ameliorates Gastrointestinal Inflammation

Research on Alleviating Gastrointestinal Inflammation by Adjusting Intestinal Circadian Rhythm through Feeding Time Background Information Impaired expression of intestinal circadian rhythm genes has been observed in biopsies from patients with inflammatory bowel disease (IBD). Disruption of circadian rhythms, such as that occurring in shift worker...

TREM2 Deficiency Reprograms Intestinal Macrophages and Microbiota to Enhance Anti–PD-1 Tumor Immunotherapy

TREM2 Deficiency Remodels Intestinal Macrophages and Microbiota to Enhance Anti-PD-1 Tumor Immunotherapy A research team from the Washington University School of Medicine, led by Blanda Di Luccia and other scientists, recently published a study in the journal Science Immunology, revealing how intestinal microbiota and tumor-associated macrophages i...