A Hierarchy of Intestinal Antigens Instructs the CD4+ T Cell Receptor Repertoire
I. Research Background The intestinal immune system must balance tolerance and defense against dietary antigens, microbiota-derived antigens, and self-antigens. Although CD4+ T cells are known to play a central role in gut immunity, how different antigen sources shape the composition of the T cell receptor (TCR) repertoire remains unclear. The trad...