Alcaligenes faecalis Induces Intestinal T Helper 17 Cells by Promoting E3 Ubiquitin Ligase TRIM21-Mediated FBXW7 Degradation

Medicine, Rheumatology and Immunology, Life Sciences, Cell Biology, Biochemistry, Immunology, Microbiology,
Alcaligenes faecalis   Th17 cells   TRIM21   FBXW7   ubiquitination   intestinal immunity   cell differentiation  

1. Research Background Intestinal Th17 cells play a central role in maintaining mucosal immune homeostasis and defending against pathogen infections. Previous studies identified segmented filamentous bacteria (SFB) as key microbes inducing intestinal Th17 cells, but controversies exist regarding SFB colonization in adult intestines: 1. Clinical Par...

A Hierarchy of Intestinal Antigens Instructs the CD4+ T Cell Receptor Repertoire

Medicine, Infectious Diseases, Rheumatology and Immunology, Gastroenterology, Life Sciences, Immunology,
intestinal immunity   T cell receptor   microbiota   dietary antigens   inflammatory bowel disease  

I. Research Background The intestinal immune system must balance tolerance and defense against dietary antigens, microbiota-derived antigens, and self-antigens. Although CD4+ T cells are known to play a central role in gut immunity, how different antigen sources shape the composition of the T cell receptor (TCR) repertoire remains unclear. The trad...

Antibiotics-Induced Intestinal Immunomodulation Attenuates Experimental Autoimmune Neuritis (EAN)

Medicine, Infectious Diseases, Rheumatology and Immunology, Neurology, Gastroenterology, Life Sciences, Immunology,
antibiotics   intestinal immunity   experimental autoimmune neuritis   immunomodulation   Guillain-Barré syndrome   gut microbiota  

Antibiotic-Induced Intestinal Immunomodulation Alleviates Experimental Autoimmune Neuritis (EAN) Academic Background Guillain-Barré syndrome (GBS) is an acute autoimmune disease that causes inflammatory demyelination of peripheral nerves. As the most common cause of acute flaccid paralysis, its global annual incidence is 1-4 cases per 100,000 peopl...