I. Academic Background and Research Motivation Atopic Dermatitis (AD) is a common chronic inflammatory skin disease characterized by eczematous lesions, intense itching, and impairment of skin barrier function. Its pathogenesis is highly complex, involving genetic susceptibility, epidermal barrier dysfunction, immune dysregulation, and environmenta...

Academic Background Stroke is one of the leading causes of adult disability globally, with the core issue being neuronal damage and neurological dysfunction. Although neurogenesis and neurorepair after stroke are considered crucial for recovery, the specific mechanisms remain incompletely understood. Recent studies have shown that immune cells play...

Background Introduction For a long time, the scientific community has generally believed that mammalian neural stem cells (NSCs) exist only in the central nervous system (CNS), particularly in specific regions of the brain, such as the dentate gyrus of the hippocampus and the subventricular zone near the lateral ventricles. NSCs in these regions ca...

Academic Background Medulloblastoma (MB) is one of the most common malignant brain tumors in children. Although recent advances in molecular characterization and multimodal treatment have significantly improved patient survival rates, the prognosis of medulloblastoma remains closely related to molecular subtypes, particularly for patients with Grou...

Spatial Transcriptomic Clocks Reveal Cell Proximity Effects in Brain Aging Academic Background With aging, cognitive function declines, and the risk of neurodegenerative diseases significantly increases. Brain aging is a complex process accompanied by numerous cellular changes. However, how aging cells affect neighboring cells and how this contribu...