Amyloid-Associated Hyperconnectivity Drives Tau Spread in Alzheimer’s Disease Academic Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by the accumulation of amyloid-beta (Aβ) plaques and the abnormal aggregation and spread of tau protein in the brain. The traditional “amyloid cascade hypothesis” posits that...

Research Progress on Early Alzheimer’s Stages: Focusing on Differences Between Objective Subtle Cognitive Difficulties and Subjective Cognitive Decline Alzheimer’s disease (AD) is a critical topic in modern neuroscience and geriatric medicine research. Its pathological process begins years before the onset of clinical symptoms. Increasing evidence ...

Research Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by the deposition of amyloid-beta (Aβ) plaques and abnormal phosphorylation of tau protein. Recent studies have increasingly highlighted the role of cerebrovascular alterations in the pathogenesis of AD. Specifically, endothelial cell damage and inflam...

Association of Plasma GFAP and p-tau-181 with Synaptic Density in Alzheimer’s Disease Academic Background Alzheimer’s Disease (AD) is a multifactorial neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ) plaques and tau protein aggregates in the brain. Recent research has shown that multiple factors are involved in the dev...

Gastrointestinal-Induced Spread of α-Synuclein and Tau Proteins Triggers Comorbid Pathology and Behavioral Impairments in Parkinson’s and Alzheimer’s Diseases Background Parkinson’s Disease (PD) and Alzheimer’s Disease (AD) are two common neurodegenerative disorders, caused by the aggregation of α-synuclein (a-syn) and Tau protein in the brain, res...