Image Classification Based on Bayesian Tensor Modeling for Alzheimer’s Disease Introduction Neuroimaging research is a crucial component of contemporary neuroscience, significantly enhancing our understanding of brain structure and function. Through these non-invasive visualization techniques, researchers can more accurately predict the risk of cer...

ADAM10-Mediated Human Prion Protein Cleavage and Its Relationship with Neurodegenerative Diseases Background The endopeptidic processing of multifunctional proteins is crucial for regulating their physiological functions and plays a significant role in various pathological conditions. Prion protein (PrP), a widely expressed glycosylphosphatidylinos...

Cerebral amyloid angiopathy (CAA) is a disease caused by the deposition of amyloid-beta (Aβ) in cerebral blood vessels. It is common not only in the elderly and almost all patients with Alzheimer’s disease (AD) but can also occur independently of other AD-related pathologies. The presence and severity of CAA promote the progression of AD-related cl...

Research Background and Objectives With over 50 million people worldwide affected by cognitive impairment disorders, this number is expected to double by 2050. Alzheimer’s disease (AD) is the most common form of dementia, characterized by extracellular amyloid-beta (Aβ) plaques and intracellular tau protein aggregates in the brain. Over the past tw...

Academic Background RNA isoforms play a critical role in gene expression regulation. On average, human protein-coding genes contain over eight RNA isoforms, leading to nearly four distinct protein-coding sequences. Traditional short-read sequencing technologies, due to their limitations in read length, cannot accurately assemble and quantify RNA is...